Hyperploidy of embryonic fibroblasts derived from Parp-1 knockout mouse
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概要
- 論文の詳細を見る
Various studies show that poly(ADP-ribose) polymerase-1 (Parp-1) is involved in genomic stability. We previously established Parp-1 knockout (Parp-1-1-) mice by disrupting Parp-1 exon 1. Parp-1-1- and Parp-1+/+ embryonic fibroblasts were isolated and they became immortalized spontaneously after two months of culture. Parp-1-1- embryonic fibroblasts showed extensive hyperploidy compared to Parp-1+1+ counterparts, and most of the cells contained a single nucleus. These results suggest that disruption of Parp-1 could result in the perturbation of chromosomal ploidy control through endoreduplication.
- 日本学士院の論文
著者
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TAKATO Tsuyoshi
Department of Oral Surgery, University of Tokyo Graduate School of Medicine
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NAKAGAMA Hitoshi
Biochemistry Division, National Cancer Center Research Institute
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Nakagama Hitoshi
Biochemistry Division National Cancer Center Research Institute
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SUGIMURA Takashi
Biochemistry Division, National Cancer Center Research Institute
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NOZAKI Tadashige
Biochemistry Division, National Cancer Center Research Institute
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FUJIHARA Hisako
Biochemistry Division, National Cancer Center Research Institute
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KAMADA Nobuo
Chugai Pharmaceutical Co., Ltd.
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SUZUKI Hiroshi
Chugai Pharmaceutical Co., Ltd.
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MASUTANI Mitsuko
Biochemistry Division, National Cancer Center Research Institute
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Nozaki T
National Cancer Center Res. Inst. Tokyo Jpn
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Kamada N
Chugai Pharmaceutical Co. Ltd. Shizuoka
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Kamada Nobuo
Chugai Pharmaceutical Co. Ltd.
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UEDA Otoya
Chugai Pharmaceutical Co., Ltd.
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Fujihara Hisako
Biochemistry Division National Cancer Center Research Institute
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Masutani Mitsuko
Biochemistry Division National Cancer Center Research Institute
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Noda T
National Cancer Center Hospital Tokyo
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Ueda Otoya
Chugai Pharmaceutical Co. Ltd.
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Takato Tsuyoshi
Department Of Oral And Maxillofacial Surgery Faculty Of Medicine University Of Tokyo
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Sugimura Takashi
Biochemistry Division National Cancer Center
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TAKATO Tsuyoshi
Department of Oral and Maxillo-facial Surgery, Faculty of Medicine, The University of Tokyo
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