Chemical synthesis of 2-amino-3-methylimidazo-[4,5-f]quinoline (IQ), a potent mutagen isolated from broiled fish.
スポンサーリンク
概要
著者
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NAGAO Minako
Biochemistry Div., Natl. Cancer Ctr. Res. Inst
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Wakabayashi Keiji
Biochemistry Division National Cancer Center Research Institute
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Sugimura Takashi
Biochemistry Division National Cancer Center
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Nishimura Susumu
Biology Division National Cancer Center Research Institute
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Kasai Hiroshi
Biology Division, National Cancer Center Research Institute
関連論文
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- HETEROCYCLIC AMINES : MUTAGENS/CARCINOGENS PRODUCED DURING COOKING OF MEAT AND FISH
- Heterocyclic amines : Mutagens/carcinogens produced during cooking of meat and fish
- Differential gene expression profiles in colon epithelium of two rat strains with distinct susceptibility to colon carcinogenesis after exposure to PhlP in combination with dietary high fat
- Parp-1 deficiency implicated in colon and liver tumorigenesis induced by azoxymethane
- Induction of Intestinal Tumors and Lymphomas in C57BL/6N Mice by a Food-borne Carcinogen, 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
- Frequent and Multiple Mutations at Minisatellite Loci in Sporadic Human Colorectal and Gastric Cancers : Possible Mechanisble Mechanistic Differences from Microsatellite Instability in Cancer Cells
- Linkage Mapping of the Bra, Brb and Brg Genes for Rat Protein Phosphatase 2A 55 kDa B-Regulatory Subunit Isotypes
- Helicobacter pylori Extracts Exhibit Nicotinamide Adenine Dinucleotide-derived Adenylation but Not Mono(adenosine 5'-diphosphate-ribosyl)ation of DNA Ligase
- Efficient Method for Rapid Induction of Aberrant Crypt Foci in Rats with 2-Amino-1-methyl-6-phenylimidazo [4,5-b] pyridine
- Isolation and Cloning of Rat Poly (ADP-Ribose) Glycohydrolase: Presence of a Potential Nuclear Export Signal Conserved in Mammalian Orthologs
- Linkage Maping of the Rat Poly(ADP-ribose) Glycohydrolase (Parg) Gene to Chromosome 16
- Presence in Pieris rapae of Cytotoxic Activity against Human Carcinoma Cells
- Difference in Target Organs in Carcinogenesis with a Heterocyclic Amine, 2-Amino-3,4-dimethylimidazo[4,5-f]quinoline, in Different Strains of Mice
- Identification of 29 Rat Genetic Markers by Arbitrarily Primed Polymerase Chain Reaction
- Rare Activation of the Human c-Ha-ras Transgene of Mice in Hemangioendothelial Sarcomas and Liver Tumors Induced by Glu-P-1
- Hepatocellular Carcinoma Induction in LEC Rats by a Low Dose of 2-Amino-3, 8-Dimenthylimidazo[4,5-f]quinoxaline
- Formation and Removal of DNA Adducts in the Liver of Rats Chronically Fed the Food-borne Carcinogen, 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline
- Inactivation of Pyrolysate Mutagens by Nitrite and by Chlorinated Tap Water (Regular Presentations) (Proceedings of the 8th Symposium on Environmental Pollutants and Toxicology)
- Structure of a NewMetabolite, Dihydroauroglaucin, Produced by Aspergillus chevalieri
- Hypertriglyceridemia in Rats Induced by Consumption of a Food-derived Carcinogen, 2-Amino-1-methyl-phenylimidazo [4,5b] pyridine (PhIP)
- DNA-binding activity of p100, a transcriptional coactivator, to single-stranded C-rich sequences
- CHEMICAL AND TOXICOLOGICAL STUDIES ON BRACKEN FERN, PTERIDIUM AQUILINUM VAR. LATIUSCULUM. IV. SURVEYS ON BRACKEN CONSTITUENTS BY MUTAGEN TEST
- Stability of centrosome numbers in poly(ADP-ribose) polymerase-1- and poly(ADP-ribose) glycohydrolase-deficient mouse ES cells
- Lack of altered frequency of sister-chromatid exchanges in poly(ADP-ribose) glycohydrolase-deficient mouse ES cells treated with methylmethanesulfonate
- Poly(ADP-ribose) polymerase-1 gene in human tumor cell lines: Its expression and structural alteration
- Developmental changes of poly(ADP-ribose) polymerase expression in Sarcophaga peregrina
- Hyperploidy of embryonic fibroblasts derived from Parp-1 knockout mouse
- Inhibition of poly(ADP-ribose) glycohydrolase activity by cyclic peptide antibiotics containing piperazic acid residues
- Phylogenic distribution of poly(ADP-ribose) glycohydrolase and poly(ADP-ribose)-digesting phosphodiesterase
- Establishment of poly(ADP-ribose) polymerase-deficient mouse embryonic stem cell lines
- CLc3 A NOVEL LYSINE-SUBSTITUTED NUCLEOSIDE IN THE FIRST POSITION OF THE ANTICODON OF MINOR ISOLEUCINE tRNA FROM Escherichia coli
- Impairment in S-phase entry of splenocytes of Parp-1 knockout mice
- Purification and characterization of poly(ADP-ribose) polymerase from Sarcophaga peregrina
- VARIETY OF PHENOTYPICAL EXPRESSION OF INTESTINAL MARKER ENZYMES AND MUCIN IN HUMAN STOMACH INTESTINAL METAPLASIA
- Atrophy of salivary glands and pancreas of rats fed on diet with amino-methyl-.ALPHA.-carboline.
- Restriction fragment length polymorphism(RFLP) of L-myc is related to the progression of human colon and stomach cancers.
- Chemical synthesis of 2-amino-3-methylimidazo-[4,5-f]quinoline (IQ), a potent mutagen isolated from broiled fish.
- Potent novel mutagens produced by broiling fish under normal conditions.
- Induction of tumors in the forestomach and liver of mice by feeding 2-amino-3,4-dimethylimidazo(4,5-f)quinoline (MeIQ).:MeIQ
- Recognition of UAG termination codon by mammalian tyrosine tRNA containing 6-thioqueuine in the first position of the anticodon.
- Preparation and characterization of monoclonal antibodies for the modified base, queuine.
- Syntheses of 2-amino-3,4-dimethyl-3H-imidazo(4,5-f)quinoline and its related compounds.
- MUTAGENIC OR DNA-MODIFYING ACTIVITIES OF N-ALKYL-N'-NITRO-N-NITROSOGUANIDINE
- Norharman and Harman in Human Urine.
- Mutagen Formation after Heating of Mixtures of Guanidino Compounds, Amino Acids and Glucose.
- Isolation and Cloning of Rat Poly(ADP-Ribose) Glycohydrolase: Presence of a Potential Nuclear Export Signal Conserved in Mammalian Orthologs.