Syntheses of 2-amino-3,4-dimethyl-3H-imidazo(4,5-f)quinoline and its related compounds.

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概要

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• The strongly mutagenic compound, 2-amino-3,4-dimethyl-3<I>H</I>-imidazo[4,5-<I>f</I>]quinoline (Me-IQ), isolated from broiled sardines was synthesized from 6-amino-7-methylquinoline. Several structurally related compounds were also synthesized to clarify the structure-activity relationship. Some of them also showed strong mutagenic activity towards <I>Salmonella typhimurium</I> TA98.

• 公益社団法人 日本化学会の論文

著者

• Nishimura Susumu

  Biology Division National Cancer Center Research Institute

• Kasai Hiroshi

  Biology Division, National Cancer Center Research Institute

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• Recognition of UAG termination codon by mammalian tyrosine tRNA containing 6-thioqueuine in the first position of the anticodon.
• Preparation and characterization of monoclonal antibodies for the modified base, queuine.
• Syntheses of 2-amino-3,4-dimethyl-3H-imidazo(4,5-f)quinoline and its related compounds.

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