Mutagen Formation after Heating of Mixtures of Guanidino Compounds, Amino Acids and Glucose.
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概要
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The effect of guanidino compounds other than creatin(in)e on mutagen formation was tested after heating with amino acid and glucose in a solution at 128°C for 2h. The mutagenicity of a heated mixture of creatine, glycine and glucose to Salmonella typhimurium TA98 with S9 mix was 630 per mg of heated material. When L-arginine was mixed with glycine plus glucose, 39 revertants of TA98 were induced per mg of heated material. Other guanidino compounds such as NG-methyl-L-arginine, 1-methylguanidine, aminoguanidine and guanidine also yielded mutagens, inducing 6.0-64 revertants per mg of heated material. When guanidino compounds were heated with L-phenylalanine and glucose, mixtures also yielded mutagenicity. The mutagenicity of a heated mixture of creatine, L-phenylalanine and glucose to TA98 with S9 mix was 160 per mg of heated material. L-Arginine, NG-methyl-L-arginine, aminoguanidine and guanidine gave 1.9-21 revertants per mg of heated material. With the addition of 1-methylguanidine, a very potent mutagenicity of 200 per mg of heated material was observed.
- 日本学士院の論文
著者
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Nagao Minako
Carcinogen. Div. Natl. Cancer Res. Inst
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Wakabayashi Keiji
Biochemistry Division National Cancer Center Research Institute
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Sugimura Takashi
Biochemistry Division National Cancer Center
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ARAKAWA Nobuhiko
Department fo Nutrition and Food Science, Ochanomizu University
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OGURI Atsuko
Biochemistry Division, National Cancer Center Research Institute
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