Effects of L-Ascorbic Acid on Lysyl Oxidase in the Formation of Collagen Cross-links(Food & Nutrition Science)
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概要
- 論文の詳細を見る
To clarify the role of L-ascorbic acid (AsA) in the formation of pyridinoline, we examined the effects of AsA in vitro using soluble collagen and partially purified lysyl oxidase from bovine aorta. The concentration of dehydrodihydroxylysinonorleucine decreased when AsA was added in the early stage of pyridinoline formation. However, when AsA was added in a later stage of pyridinoline formation, the concentration of pyridinoline was not affected. These findings indicated that AsA was involved in the initial enzymatic reaction in pyridinoline synthesis. We purified lysyl oxidase to confirm its association of AsA. AsA inhibited the enzyme activity. Erythorbic acid and 3, 4-dihydroxybenzoate suppressed the enzyme activity as well as AsA did. The inhibition by AsA of the lysyl oxidase activity arose from characteristics of AsA structure. AsA might be important in the regulation of the oxidative reaction of lysine.
- 社団法人日本農芸化学会の論文
- 2002-10-23
著者
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FUJIWARA Yoko
Department of Food Science and Nutrition, Ochanomizu University
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Otsuka Minoru
Department Of Bioresource Engineering Yamagata University
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Kim M
Taiyo Kagaku Co. Ltd. Mie Jpn
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KUROYANAGI Miwa
Department of Botany, Graduate School of Science, Kyoto University
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Fujiwara-hatano Yoko
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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OTSUKA Megumi
Department of Nutrition & Food Science, Ochanomizu University
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ARAKAWA Nobuhiko
Department of Nutrition & Food Science, Ochanomizu University
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SHIMAMURA Eriko
Department of Nutrition and Food Science, Ochanomizu University
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KIM Mihyan
Department of Nutrition and Food Science, Ochanomizu University
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Kim M
Department Of Nutrition And Food Science Ochanomizu University
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Kuroyanagi Miwa
Department Of Botany Graduate School Of Science Kyoto University
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Kuroyanagi Miwa
Department Of Nutrition And Food Science Ochanomizu University
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Fujiwara Yoko
Graduate School Of Humanities And Sciences Ochanomizu Univ.
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Fujiwara Yoko
Department Of Nutrition And Food Science Ochanomizu University
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Kim Mihyan
Department Of Nutrition And Food Science Ochanomizu University
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Fujiwara Yoko
Department Of Food Science And Nutrition Ochanomizu University
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Shimamura Eriko
Department Of Nutrition And Food Science Ochanomizu University
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Shimamura Eriko
Department Of Anatomy Kanazawa Medical University
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Arakawa N
Department Of Nutrition And Food Science Ochanomizu University
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Fujiwara Yoko
Department Of Food And Nutritional Science Graduate School Of Humanities And Sciences Ochanomizu University
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OTSUKA Megumi
Department fo Nutrition and Food Science, Ochanomizu University
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ARAKAWA Nobuhiko
Department fo Nutrition and Food Science, Ochanomizu University
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FUJIWARA Yoko
Division of Molecular Pharmacology, Department of Pharmacology, Jichi Medical University
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FUJIWARA Yoko
Department of Nutrition and Food Science, Ochanomizu University
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Fujiwara Yoko
Department of Food and Nutrition, Ochanomizu University
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