Age-Related Changes in the Pyridinoline Content of Guinea Pigs Cartilage and Achilles Tendon Collagen.
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概要
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Age-related changes of pyridinoline, a mature cross-link of collagen fibers, in tissues of guinea pigs which cannot synthesize L-ascorbic acid (AsA) were investigated. Male guinea pigs, 2 weeks old, were fed a commercial diet unitil they were 40 weeks old. Based on the data of body weight gain, it is assumed that guinea pigs require 10 weeks to reach maturity. The content of AsA in serum, adrenals, and liver of the animals increased with growth, then decreased after 8-10 weeks. The pyridinoline content in cartilage and tendon collagen was very low in 2-week-old animals, whereas it increased markedly with growth. After 10 weeks, the pyridinoline tended to decrease in cartilage collagen; however, it was not changed in tendon collagen. The age-related changes of pyridinoline content in guinea pigs cartilage were similar to those of humans-increasing with growth and decreasing after adolescence.
- 財団法人 学会誌刊行センターの論文
著者
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Kim Mihyang
Department Of Food And Nutrition Silla University:marine Biotechnology Center For Bio-functional Mat
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ARAKAWA Nobuhiko
Department of Nutrition and Food Science, Ochanomizu University
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OTSUKA Megumi
Department fo Nutrition and Food Science, Ochanomizu University
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ARAKAWA Nobuhiko
Department fo Nutrition and Food Science, Ochanomizu University
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KIM Mihyang
Department of Nutrition and Food Science, Ochanomizu University
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