Evaluation of Urinary Pyridinoline in Healthy Adults and Patients with Rheumatoid Arthritis by an Improved High-performance Liquid Chromatographic Assay
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概要
- 論文の詳細を見る
A modified method for the determination of pyridinoline using high-performance liquid chromatography (HPLC) has been applied to analyze the urine of healthy adults and patients with rheumatoid arthritis. The concentrations of pyridinoline in the urine of healthy Japanese men and women (average age: 50.6 and 51.8 yr, respectively) during morning fasting were 28.8±2.8 (SEM) and 34.8±3.5 nmol/mmol creatinine, respectively. In the case of patients with rheumatoid arthritis, the urinary concentration of pyridinoline was 49.1±8.3 nmol/mmol creatinine (women, average age, 61.1 yr), which was significantly higher than that of healthy women of the same age (p<0.05). This study supports the application of HPLC for urinary pyridinoline analysis and as a screening test for patients with bone disease.
- 財団法人 学会誌刊行センターの論文
著者
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Kawai Shinichi
Institute Of Medical Science St. Marianna University School Of Medicine
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Kim Jong-suk
Department Of Biochemistry Chonbuk National University Medical School And Institute For Medical Scie
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OTSUKA Megumi
Department of Nutrition & Food Science, Ochanomizu University
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KUROSAKA Reiko
Department of Nutrition and Food Science, Ochanomizu University
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ARAKAW Nobuhiko
Department of Nutrition and Food Science, Ochanomizu University
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KAWAI SHINICHI
Institute of Medical Science, St. Marianna University School of Medicine
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KIM Jong-Suk
Department of Nursing Education, Korea University
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OTSUKA Megumi
Department fo Nutrition and Food Science, Ochanomizu University
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