The Penile Erection Efficacy of a New Phosphodiesterase Type 5 Inhibitor, Mirodenafil (SK3530), in Rabbits with Acute Spinal Cord Injury(Pharmacology)
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概要
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Mirodenafil (SK3530) is a new potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5). Recent clinical trials have demonstrated that mirodenafil is an effective treatment for erectile dysfunction. Its mechanism of action is enhancement of nitric oxide (NO) induced cGMP formation resulting in significant relaxation of the corpus cavernosum (CC). The aim of this study was to investigate the oral efficacy of mirodenafil in an acute spinal cord-injured rabbit model. Mirodenafil or sildenafil citrate was given orally to male rabbits with a surgical transection of the spinal cord at the L2-L4 lumbar vertebra or ischemic-reperfusion spinal cord injury (SCI). Erections were evaluated in a time-course manner by measuring the length of the uncovered penile mucosa. In the transection SCI model, penile erections were induced at 0.3, 1 and 3mg/kg of mirodenafil but sildenafil only showed an erectile response at 3mg/kg. The effects of 1 and 3mg/kg of mirodenafil were significantly increased by intravenous injection of sodium nitroprusside (SNP), a nitric oxide donor. In the ischemic-reperfusion injury model, 3mg/kg of either mirodenafil or sildenafil produced a penile erection response. After injection of SNP, the lengths of immediate penile erections were significantly increased in the 1 and 3mg/kg mirodenafil and 3mg/kg sildenafil groups. The onset of erectile activity was faster with mirodenafil than with sildenafil citrate. These results demonstrate that mirodenafil may be useful for treating erectile dysfunction in patients with a spinal cord injury.
- 社団法人日本獣医学会の論文
- 2008-11-25
著者
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LEE Yong-Soon
Departments of Veterinary Public Health, College of Veterinary Medicine and School of Agricultural B
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CHOI Changsun
Department of Veterinary Pathology, College of Veterinary Medicine and School of Agricultural Biotec
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Kim Byeong-soo
Department Of Companion And Laboratory Animal Science Kongju National University
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Kim So-jung
Department Of Pediatric Dentistry And Institute Of Oral Biology School Of Dentistry Kyung Hee Univer
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Park Young-seok
Department Of Companion And Laboratory Animal Science Kongju National University
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JUNG Ji-Youn
Department of Companion and Laboratory Animal Science, Kongju National University
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KIM Sang-Ki
Department of Companion and Laboratory Animal Science, Kongju National University
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LEE Seung-Ho
Department of Companion and Laboratory Animal Science, Kongju National University
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YOON Seong-Il
Department of Life Science, College of Natural Sciences, Hanyang University
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KIM Jong-Suk
Department of Biochemistry, Institute of Medical Science, Chunbuk National University Medical School
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CHO Sung-Dae
Department of Oral Pathology, School of Dentistry, Chonbuk National University
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IM Gwang-Jin
Life Science Research Center, SK Chemicals
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LEE Soo-Min
Life Science Research Center, SK Chemicals
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JUNG Ji-Won
Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University
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Jung Ji-youn
Department Of Companion And Laboratory Animal Science Kongju National University
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Kim Sang-ki
Department Of Companion And Laboratory Animal Science Kongju National University
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Lee Soo-min
Life Science Research Center Sk Chemicals
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Cho Sung-dae
Department Of Oral Pathology School Of Dentistry Chonbuk National University
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Im Gwang-jin
Life Science Research Center Sk Chemicals
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Yoon Seong-il
Department Of Life Science College Of Natural Sciences Hanyang University
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Kim Jong-suk
Department Of Biochemistry Chonbuk National University Medical School And Institute For Medical Scie
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Kim Jong-suk
Department Of Biochemistry Institute Of Medical Science Chunbuk National University Medical School
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Kim So-jung
Department Of Material Science And Engineering
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Lee Seung-ho
Department Of Companion And Laboratory Animal Science Kongju National University
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Choi Changsun
Department Of Food And Nutrition College Of Human Ecology Chung-ang University
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Lee Yong-soon
Department Of Public Health College Of Veterinary Medicine Seoul National University
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Cho Sung-dae
Department Of Oral Pathology School Of Dentistry And Institute Of Oral Bioscience Brain Korea 21 Pro
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