ペルオキシソーム増殖薬とphenytoinが引き起こす肝毒性のcDNAマイクロアレイ法による遺伝子発現解析(毒性学)
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概要
- 論文の詳細を見る
DNAマイクロアレイ法は,膨大な量の遺伝子発現プロファイルを解析することができるため,トキシコゲノミクス分野における有効なツールの一つである.我々は,今回,肝毒性を引き起こす化学物質をin vivoで投与し,マイクロアレイ解析結果から,各化合物のcharacterizationを行ったので報告する.我々はペルオキシソーム増殖薬であるclofibrate,gemfibrozilおよび抗〓癇薬であるphenytoinを5-6週齢のSDラット(VAF/plus)に24時間あるいは2週間投与し,4800遺伝子について,マイクロアレイ法を用いて発現プロファイルを解析した.遺伝子発現クラスター解析から,同じ毒性作用を示す化合物ごとに,遺伝子変動をグルーピングすることができることが明らかになった.
- 社団法人日本獣医学会の論文
- 2004-11-25
著者
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KANG Kyung-Sun
Departments of Veterinary Public Health, College of Veterinary Medicine and School of Agricultural B
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LEE Yong-Soon
Departments of Veterinary Public Health, College of Veterinary Medicine and School of Agricultural B
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HWANG Seung
Department of Biochemistry, Hanyang University & GenoCheck Co. Ltd.
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KANG Kyung-Sun
獣医公衆衛生学講座
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Kang Kyung-sun
韓国
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LI Peng
Department of Physics and Information Engineering, Jining University
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Lee Yong-soon
韓国
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Hwang Jae-woong
Laboratory Of Stem Cell And Tumor Biology Department Of Veterinary Public Health College Of Veterina
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Kim Y‐h
Bioimformatics Unit Istech Inc.:cancer Metastasis Research Center Yonsei University College Of Medic
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Jung Jin-wook
Laboratory Of Stem Cell And Tumor Biology Department Of Veterinary Public Health College Of Veterina
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Li Peng
Department Of Physics And Information Engineering Jining University
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Kim Yang-suk
Bioimformatics Unit Istech Inc.:cancer Metastasis Research Center Yonsei University College Of Medic
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Lee Wan-seon
Bioimformatics Unit Istech Inc.
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Lee Gyoung-jae
Research Institute. Shin-won Scientific Co. Ltd.
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金 龍丸
光州保健環境研究所
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Hwang Seung
Department Of Biochemistry And Molecular Biology Hanyang University & Genocheck Co. Ltd.
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Lee Yong-soon
中華人民共和国
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Kang Kyung-sun
Department Of Veterinary Public Health College Of Veterinary Medicine Seoul National University
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YEO Chan-Dong
Research Institute, Shin-Won Scientific Co., Ltd.
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KANG Jong-Soo
Research Institute, Shin-Won Scientific Co., Ltd.
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PARK Joon-Suk
Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University
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HWANG Jae-Woong
Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University
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JEON Ki-Seon
Bioinformatics Unit, ISTECH Inc.
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UM Chan-Hwi
Bioinformatics Unit, ISTECH Inc.
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Yeo Chan-dong
Research Institute. Shin-won Scientific Co. Ltd.
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PARK Jung-Eun
Department of Neurology, Clinical Research Institute, Seoul National University Hospital
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Park Joon‐suk
Seoul National Univ. Seoul Kor
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Jeon Ki-seon
Bioimformatics Unit Istech Inc.
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JUNG Jin-Wook
Department of Dermatology, Chonnam University Medical School
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Jung Jin-wook
Department Of Dermatology Chonnam University Medical School
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Oh Moon-Ju
Department of Biochemistry, Hanyang University & GenoCheck Co., Ltd.
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SONG Bog-Soo
Research Institute. Shin-Won Scientific Co., Ltd.
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UM Chan-Hwi
Bioimformatics Unit, ISTECH Inc.
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YOUN Jong-Pil
Department of Biochemistry and Molecular Biology, Hanyang University & Genocheck Co., Ltd.
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Youn Jong-pil
Department Of Biochemistry And Molecular Biology Hanyang University & Genocheck Co. Ltd.
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Um Chan-hwi
Bioimformatics Unit Istech Inc.
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Park Joon-suk
Department Of Pediatrics & Human Development ; And The National Food Safety & Toxicology Cen
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Kang Jong-soo
Research Institute. Shin-won Scientific Co. Ltd.
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Song Bog-soo
Research Institute. Shin-won Scientific Co. Ltd.
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Park Jung-eun
Department Of Chemistry Seoul National University
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Lee Yong-soon
Department Of Veterinary Public Health College Of Veterinary Medicine Seoul National University:scho
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Lee Yong-soon
Department Of Public Health College Of Veterinary Medicine Seoul National University
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Li Peng
Department Of Biochemistry And Molecular Biology Hanyang University & Genocheck Co. Ltd.
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Park Jie-Eun
Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University:School of Agricultural Biotechnology, Seoul National University
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LEE Yong-Soon
Laboratory of Stem Cell and Tumor Biology, Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University
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OH Moon-Ju
Department of Biochemistry and Molecular Biology, Hanyang University & Genocheck Co., Ltd.
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