ラット神経幹細胞の分化におけるギャップジャンクション細胞間コミュニケーション (GJIC) の役割 : p38 および ERK1/2 経路の関与(毒性学)
スポンサーリンク
概要
- 論文の詳細を見る
ギャップジャンクションを介する細胞間コミュニケーション(GJIC)は中枢神経系の発達と分化に重要な役割を果たしている.本研究では, ラット脳より得た神経幹細胞および12-tetradecanoylphorbol-13-acetate (TPA)で誘導した神経幹細胞由来の細胞の分化過程におけるGJICの発現について検討した.神経幹細胞の分化過程の初期72時間以内ではCx43, Cx32の増加が見られた.神経幹細胞由来の細胞では, p38 MAPキナーゼを阻害するSB203580およびMEKを阻害するPD98059がTPAによるGJICの阻害からGJICを保護することが分かった.これらから, GJICは神経幹細胞の分化に重要な役割を果たしており, ERK7/2およびp38 MAPキナーゼシグナリング経路は機能的にラット神経幹細胞由来細胞のギャップジャンクションの調節に関与している可能性が考えられた.
- 社団法人日本獣医学会の論文
- 2005-03-25
著者
-
PARK Joon
Department of Chemical Engineering, Chungnam National University
-
Kim Tae
Department Of Materials Science And Engineering Korea Advanced Institute Of Science And Technology
-
HWANG Jae
Department of wind engineering, Hyundai Institute of Construction Technology
-
Cho Sung
Department Of Urology Seoul National University Hospital
-
JUNG Ji
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The Universit
-
Kang Kyung
Department Of Veterinary Public Health College Of Veterinary Medicine Seoul National University
-
LEE Yong
Department of Materials Science & Engineering, Sungkyunkwan University
-
Park Joon
Department Of Biotechnology Graduate School Of Engineering Osaka University
-
Lee Bong
Department Of Anatomy And Neurobiology College Of Medicine Institute Of Medical Science Cheju Nation
-
JO Eun
Department of Chemical Engineering, Konkuk University
-
Hwang Jae
Department Of Agricultural Biology National Institute Of Agricultural Science And Technology
-
Jung Ju
Department Of Anatomy College Of Medicine Hallym University
-
Kim Tae
Department Of Veterinary Public Health College Of Veterinary Medicine Seoul National University
-
Kang Kyung-sun
ソウル大学獣医科大学農業生物工学科獣医公衆衛生学講座
-
Park Joon‐suk
Seoul National Univ. Seoul Kor
-
Jung Ji
Department Of Genetic Epidemiology Snp Genetics Inc.
-
YANG Se
Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University
-
AHN Nam
Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University
-
YOON Byoung
Laboratory of Genetics, Department of Biology, College of Natural Science, Kyonggi University
-
Yang Se‐ran
Seoul National Univ. Seoul Kor
-
Yang Se-ran
Department Of Veterinary Public Health College Of Veterinary Medicine Seoul National University:scho
-
Jung Ji
Department Of Veterinary Public Health College Of Veterinary Medicine Seoul National University
-
Cho Sung‐dae
Chonbuk National Univ. Jeonju
-
Lee Y.-h.
韓国
-
Lee Yong
Department Of Agricultural Chemistry Division Of Applied Life Science Graduate School Gyeongsang Nat
-
Jo Eun‐hye
Seoul National Univ. Seoul Kor
-
Jo Eun
Department Of Chemical Engineering Konkuk University
-
Ahn Nam
Department Of Veterinary Public Health College Of Veterinary Medicine Seoul National University
-
Yoon Byoung
Laboratory Of Genetics Department Of Biology College Of Natural Science Kyonggi University
-
Lee Yong‐soon
Seoul National Univ. Seoul Kor
-
Cho Sung
Department Of Anatomy Seoul National University College Of Medicine
-
Kim Tae
Department Of Anesthesia And Pain Medicine School Of Medicine Pusan National University
-
Hwang Jae‐woong
Seoul National Univ. Seoul Kor
-
Kang Kyung
Department Of Internal Medicine Seoul National University Bundang Hospital
-
Cho Sung-dae
Department Of Oral Pathology School Of Dentistry And Institute Of Oral Bioscience Brain Korea 21 Pro
-
Park Joon
Department Of Biomedical Engineering College Of Engineering University Of Iowa
-
Lee Yong
Depart. Of Oncology Yonsei Univ. Wonju College Of Medicine
-
Ahn Nam-Shik
Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University
-
JUNG Ji
Department of Anatomy, College of Medicine, Hallym University
-
Kim Tae
Department of Advanced Materials Engineering, Sungkyunkwan University, Suwon, Gyeonggi 440-746, Republic Korea
関連論文
- Identification and analysis of specific chromosomal region adjacent to exogenous Dhfr-amplified region in Chinese hamster ovary cell genome(CELL AND TISSUE ENGINEERING)
- Ibuprofen Racemate Separation by Simulated Moving Bed
- Regression of Giant Bullous Emphysema
- IS-59 The study of tissue mineral concentration in pregnant women who lived in Incheon and outcome of pregnancy(Group8 Perinatology1,International Session)
- Postprocessing in Block-Based Video Coding Based on a Quantization Noise Model(Image Processing and Video Processing)
- Robust Control of Wind-induced Vibration for Suwon Observation Tower
- AN-P5 Effects of palindrome structure on dihydrofolate reductase gene amplification in Chinese hamster ovary cells(Section I Animal and Plant Cell Cultures)
- AN-O10 Bacterial artificial chromosome library for genome-wide analysis of Chinese hamster ovary cells(Section I Animal and Plant Cell Cultures)
- Characterization of SiC:H films deposited using HMDS precursor with C_2H_2 dilution gas by remote PECVD system
- Analysis of Interface trap between pentacene active layer and gate insulator of OTFTs
- Shape and Interband Transition Behavior of InAs Quantum Dots Dependent on Number of Stacking Cycles
- Development and Industry of Health Functional Food in Korea
- Effects of Indium-Tin-Oxide Surface Treatment on Organic Light-Emitting Diodes
- Dependence of Buffer Layer on the Distribution of InAs Quantum Dots
- Facet Evolution of Al_Ga_As/GaAs Multilayers Grown on Mesa-Patterned GaAs Substrate
- Protective Effects of Panduratin A against Oxidative Damage of tert-Butylhydroperoxide in Human HepG2 Cells(Pharmacology)
- Serotonin-induced ion channel modulations in mesenteric artery myocytes from normotensive and DOCA-salt hypertensive rats
- Fabrication of Polyaniline Silica Nanotubes and Closed Polyaniline Nanotubes Using a Template of Silica Nanotube
- Fluorescent Calix[4]arene-appended Silica Nanotubes as Selective Chemosensor and Adsorbent for Pb^ Ion
- A Cytogenetic Study of Korean Native Goat Bred in the Nuclear Power Plant using the Micronucleus Assay
- Antimalarial Activity of Herbal Extracts Used in Traditional Medicine in Korea(Pharmacognosy)
- Efficient Quenching of the Fluorescence of Aromatic Guests by β-Cyclodextrin-Tethered Viologens via Inclusion Complexation
- FMRFamide-Expressing Efferent Neurons in Eighth Abdominal Ganglion Innervate Hindgut in the Silkworm, Bombyx mori(Neurobiology)
- Effects of 20-Hydroxyecdysone and Serotonin on Neurite Growth and Survival Rate of Antennal Lobe Neurons in Pupal Stage of the Silk Moth Bombyx mori in vitro(Neurobiology)
- 韓国における牛海綿状脳症のリスクアナリシス
- ラット神経幹細胞の分化におけるギャップジャンクション細胞間コミュニケーション (GJIC) の役割 : p38 および ERK1/2 経路の関与(毒性学)
- Structural Insights of the Nucleotide-Dependent Conformational Changes of Thermotoga maritima MutL Using Small-Angle X-ray Scattering Analysis
- Effects of 2-bromopropane on the female reproductive function in Sprague-Dawley rats.
- Circling Mouse, a Spontaneous Mutant in the Inner Ear
- Sulfide Capacity and Phase Equilibria of MnO-TiO_2MnS System at 1723 K
- Majocchi's granuloma in a woman with iatrogenic Cushing's syndrome
- Post-steroid panniculitis in an adult
- Geometric Structure for the Uniform Splay-to-Bend Transition in a π-Cell
- OPT-05 FEASIBILITY ANALYSIS IN THE APPLICATION OF RADIALLY POLARIZATION TO NEAR-FIELD OPTICAL MICROSCOPY(Optical Storage/Optical Devices for Storage II,Technical Program of Oral Presentations)
- ^F-FDG PET imaging of progressive massive fibrosis
- Changing pattern of antimicrobial resistance of Helicobacter pylori in Korean patients with peptic ulcer diseases
- Systemic Inflammatory Syndrome and Hepatic Inflammatory Cell Infiltration Caused by an Interleukin-6 Producing Pheochromocytoma
- Inhibitory Effects of Active Compounds Isolated from Safflower (Carthamus tinctorius L.) Seeds for Melanogenesis(Pharmacognosy)
- Formation of p-Type Hg_Cd_Te Epilayers Grown on CdTe Buffer Layers on GaAs (211) B due to In Situ Thermal Annealing
- Hydrogenation and Annealing Effects on Deep Levels in Unintentionally Doped n-Type GaN Epilayers Grown on Sapphire Substrates : Semiconductors
- Activation Energy, Capture Cross Section, and Emission Frequency of the Trap Level in Unintentionally Doped n-Type GaN Epilayers Grown on Sapphire Substrates in a Nitrogen-Rich Atmosphere
- Annealing Effect on Passivated Deep Levels in GaN Epilayers
- Structural Characterization of a Mo/Ru/Si Extreme Ultraviolet (EUV) Reflector by Optical Modeling
- Microwave Dielectric Properties and Far Infrared Reflectivity Spectra of the (Zr_Sn_)TiO_4 Ceramics with Additives
- Molecular Characterization of a cDNA from the Silk Moth Bombyx mori Encoding Manduca sexta Allatotropin Peptide(Molecular Biology)
- Redifferentiation Therapy with 13-cis Retinoic Acids in Radioiodine-Resistant Thyroid Cancer
- Sporotrichoid Dermatosis Caused by Mycobacterium abscessus from a Public Bath
- チリダニ類, コナヒョウヒダニとヤケヒョウヒダニの大量飼育
- Clinical Characteristics of Primary Thyroid Lymphoma in Koreans
- Clinical Features and Prognostic Factors for Survival in Patients with Poorly Differentiated Thyroid Carcinoma and Comparison to the Patients with the Aggressive Variants of Papillary Thyroid Carcinoma
- Enantioseparation of racemic N-acylarylalkylamines on various amino alcohol derived π-acidic chiral stationary phases
- Dependence of the Surface, the Structural, and the Optical Properties on the Thickness of the AIN Buffer Layer for GaN Epilayers Grown on Sapphire Substrates : Semiconductors
- Berberine-Induced Apoptosis in Human Glioblastoma T98G Cells Is Mediated by Endoplasmic Reticulum Stress Accompanying Reactive Oxygen Species and Mitochondrial Dysfunction
- First-line therapy with doxycycline in ocular adnexal mucosa-associated lymphoid tissue lymphoma : A retrospective analysis of clinical predictors
- Performance Analysis of IEEE 802.11 DCF and IEEE 802.11e EDCA in Non-saturation Condition
- The Expression of Melanogenic Proteins in Korean Skin after Ultraviolet Irradiation
- Reliability Analysis of a Suspension Bridge Affected by Hydrogen Induced Cracking Based upon Response Surface Method
- Acrodermatitis enteropathica with anorexia nervosa
- Prediction of Ultimate Behaviors in Cold-formed Steel Bolted Connection by the Introduction of Initial Geometric Imperfection in FE Modeling
- Effects of aerobic and resistance training on the health-related physical fitness and serum lipids in elderly women
- COMMON FIXED POINT THEOREMS RELATING TO THE DIAMETER OF ORBITS
- COMMON FIXED POINT THEOREMS FOR A GENERALIZED CONTRACTION
- Isolation of Mesenchymal Stem Cells from Cryopreserved Human Umbilical Cord Blood
- Use of a recombinant Clonorchis sinensis pore-forming peptide, colonorin, for serological diagnosis of clonorchiasis
- Nanomechanical Behavior of β-SiC Nanowire in Tension : Molecular Dynamics Simulations
- Primary immature teratoma of the prostate with angiosarcoma component : Its unusual response to chemotherapy
- Moyamoya disease-induced hemichorea corrected by indirect bypass surgery
- 1.55 μm Wavelength Strain-Compensated In_χGa_As/In_yAl_As Electroabsorption Modulators with High Extinction Ratio and Low Polarization-Dependent Loss
- EC_ of remifentanil to prevent withdrawal movement associated with injection of rocuronium
- Dissociative Photoionization of Bis(dimethyl-μ-isopropylamido-aluminum) and Bis(dimethyl-μ-t-butylamido-aluminum) in the Region hν=65-133 eV by Mass Spectrometry
- Molecular Recognition of Organic Ammonium Ions by Diaza0Crown Ether-Modified β-Cyclodextrin in Aqueous Media
- Effects of Sulfur Treatment and Hydrogen Plasma Treatment on GaAs
- Nitric Oxide Modulation of the Spontaneous Firing of Rat Medial Vestibular Nuclear Neurons
- Effects of Thermal Annealing on the Au/Ni and the Au/Ni/Si/Ni Contact Properties of p-type GaN Epilayers
- Endothelium-Dependent Vasodilatory and Hypotensive Effects of Crotalaria Sessiliflora L. in Rats(Pharmacology)
- Enhancement of the Programming Speed in SANOS Nonvolatile Memory Device Designed Utilizing Al_2O_3 and SiO_2 Stacked Tunneling Layers
- Effects of the Substitution of Nonmagnetic Ions in Bi-YIG Coating Films on the Magneto-Optical Properties (特集 磁性材料の化学)
- Role of Graft Tension in Tibial Tunnel Placement
- 豚のアルコール性肝障害に対する生物学的に活性なセラミックウォーターの防御作用(病理学)
- コレステロールとコール酸ナトリウム食給餌ラットにおける軽度の肝線維症(病理学)
- A Low Power Highly linear Cascoded Multiple Gated Transistor CMOS RF Amplifier with 10dB IP3 Improvement
- A Low Power Highly linear Cascoded Multiple Gated Transistor CMOS RF Amplifier with 10dB IP3 Improvement
- Effect of dominant hemispheric stroke on detrusor function in patients with lower urinary tract symptoms
- MN-O11 High-performance swCNT-FET-based bioelectronic tongue using human taste receptor protein(Section X Micro/Nano Technology for Analysis and Cell Manipulation)
- The Enhancement of 1-Butene Selectivity in the Hydrogenation of 1,3-Butadiene over K-Ni Catalysts
- Gastroesophageal flap valve is associated with gastroesophageal and gastropharyngeal reflux
- A Case of Edematous Striae Distensae in Lupus Nephritis
- ハッカ細胞の二相培養による精油生産の向上
- Effects of Hydrogenation and Annealing on the Deep Levels in GaN Epilayers Grown on Sapphire Substrates
- A Case of Hypohidrotic Ectodermal Dysplasia
- DEMI: A Delay Minimization Algorithm for Cell-Based Digital VLSI Design
- Fractal dimensions for the fibres of certain type of carpets
- GENERALIZED TRI-QUASI-VARIATIONAL INEQUALITIES
- Influences of Indium Tin Oxide Layer on the Properties of IF Magnetron-Sputtered (BaSr)TiO_3 Thin Filmson Indium Tin Oxide-Coated Glass Substrate
- Adsorption Kinetics aNd Behaviors of Cellulase Components on Microcrystalline Cellulose
- Alternative Splicing of Type II Procollagen Gene in the Dedifferentiation of Rat Epiphyseal Chondrocytes Serially Cultured in Monolayer
- High Prevalence of Bronchiectasis in Adults : Analysis of CT Findings in a Health Screening Program
- Postoperative blindness associated with posterior reversible encephalopathy syndrome : a case report
- Combined general and epidural anesthesia for major abdominal surgery in a patient with Pompe disease
- Crystal Structure of Cs(18-Crown-6)I・2H_2O