Serotonin-induced ion channel modulations in mesenteric artery myocytes from normotensive and DOCA-salt hypertensive rats

スポンサーリンク

概要

• 論文の詳細を見る

• Although serotonin (5-hydroxytryptamine, 5-HT) has been found to be a potent vasoconstrictor, a pivotal role of 5-HT in the control of appetite and mood control by the modulation of neuronal synapse has also been proposed. Selective 5-HT reuptake inhibitors (SSRIs) are frequently used to suppress appetite and treat depressive disorder, and the target protein of SSRIs is the 5-HT transporter (5-HTT) in the neuronal synapse. However, SSRIs may increase the free 5-HT concentration in circulating blood because platelets and vascular smooth muscles express functional 5-HTT. In addition, enhanced vasoactive action of 5-HT and alterations in 5-HT receptor subtypes have been reported in some types of hypertension. Therefore, we can infer that the use of drugs such as SSRIs in some hypertensive patients is potentially risky. Altered functional expression of ion channels in vascular smooth muscle is suggested to be a mechanism for the enhanced vasoconstriction by vasoactive agonists, including 5-HT. In this brief review, we compared the electrophysiological properties of mesenteric artery myocytes and their modulation by 5-HT between sham-operated control and deoxycorticosterone acetate (DOCA)-salt hypertensive rats.

著者

• Cho Sung

  Department Of Urology Seoul National University Hospital

• Kim Bokyung

  Department Of Physiology & Immunology School Of Medicine Konkuk University

• Kim Bokyung

  Department Of Physiology College Of Medicine Konkuk University

• Sung Dong

  Artificial Muscle Research Center:department Of Physiology College Of Medicine Konkuk University

• KIM Junghwan

  Department of Physical Therapy, College of Natural Science, Yongin University

• Cho Sung

  Department Of Physiology College Of Medicine Konkuk University

• Bae Young

  Dep. Of Medicine Coll. Of Medicine Konkuk Univ. Kor

• Kim Junghwan

  Department Of Physical Therapy College Of Natural Science Yongin University

• Cho Sung

  Department Of Anatomy Seoul National University College Of Medicine

• Noh Hyun

  Department Of Physiology College Of Medicine Konkuk University

• BAE Young

  Artificial Muscle Research Center

• PARK Sang

  Artificial Muscle Research Center

• Park Sang

  Artificial Muscle Research Center:department Of Physiology College Of Medicine Konkuk University

• KIM Bokyung

  Department of Medicine, Konkuk University

関連論文

• Characterization of SiC:H films deposited using HMDS precursor with C_2H_2 dilution gas by remote PECVD system
• Serotonin-induced ion channel modulations in mesenteric artery myocytes from normotensive and DOCA-salt hypertensive rats
• Hydrogen Adsortion in Periodic Mesoporous Organic- and Inorganic-Silica Materials at Room Temperature
• Effect of amniotic membrane on induced expression of iNOS by exposure to stimulants in HaCaT cells
• ラット神経幹細胞の分化におけるギャップジャンクション細胞間コミュニケーション (GJIC) の役割 : p38 および ERK1/2 経路の関与(毒性学)
• p38 Mitogen-Activated Protein Kinase Regulates Vasoconstriction in Spontaneously Hypertensive Rats
• Endothelin-1 Induces Contraction via a Syk-Mediated p38 Mitogen-Activated Protein Kinase Pathway in Rat Aortic Smooth Muscle
• Epidermal Growth Factor Induces Vasoconstriction Through the Phosphatidylinositol 3-Kinase-Mediated Mitogen-Activated Protein Kinase Pathway in Hypertensive Rats
• c-Jun N-terminal Kinase Contributes to Norepinephrine-Induced Contraction Through Phosphorylation of Caldesmon in Rat Aortic Smooth Muscle
• Cordycepin Attenuates Neointimal Formation by Inhibiting Reactive Oxygen Species-Mediated Responses in Vascular Smooth Muscle Cells in Rats
• Cofilin Phosphorylation Mediates Proliferation in Response to Platelet-Derived Growth Factor-BB in Rat Aortic Smooth Muscle Cells
• p38 Mitogen-Activated Protein Kinase Contributes to Angiotensin II-Stimulated Migration of Rat Aortic Smooth Muscle Cells
• 肺動脈平滑筋のホルボールエステルによるCa非依存性収縮にはCdc42が関与する(薬理学)
• タモキシフェンはMAPKの抑制を介してラット大動脈平滑筋を弛緩させる(薬理学)
• ラット大動脈におけるMAPK依存性・ミオシンリン酸化非依存性のエンドセリン収縮
• O-2-63 Transgastric Endoscopic Cholecystectomy of the Porcine Model
• Effects of Hibarimicins and Hibarimicin-Related Compounds Produced by Microbispora on v-Src Kinase Activity and Growth and Differentiation of Human Myeloid Leukemia HL-60 Cells
• Coexistence of Behcet's Disease and Autoimmune Disease : Clinical Features of 11 Cases
• cDNA Cloning and Expression of an Aminoalcoholphosphotransferase Isoform in Chinese Cabbage
• Zincoaluminophosphate Molecular Sieves with AFI and ATS Topologies : Synthesis by Dry-Gel Conversion Methods and Their Catalytic Properties in the Isopropylation of Biphenyl
• The Topographical Selectivity in Pd-Activated Electroless Copper Deposition
• The Tepographical Selectivity in Pd-Activated Electroless Copper Deposition
• Effects of starvation on morphometric characteristics of olive flounder, Paralichthys olivaceus
• Rational Type of Laparoscopic Hysterectomy and Safety in Anesthetic Profiles
• Two Uterine Arterial Management Methods in Laparoscopic Hysterectomy
• Changes in Corneal Endothelial Cell Density in Patients with Normal-Tension Glaucoma
• Burn scars treated by pinhole method using a carbon dioxide laser
• Differential Regulation of MAPK Isoforms during Cast-Immobilization : Induced Atrophy in Rat Gastrocnemius Muscle
• An Acoustic Echo Cancellation Based on the Adaptive Lattice-Transversal Joint (LTJ) Filter Structure
• Expression of E- and N-cadherin and clinicopathology in hepatocellular carcinoma
• Subungual Extraskeletal Chondroma Mimicking Glomus Tumor
• Antioxidative Activity of Resveratrol and Its Derivatives Isolated from Seeds of Paeonia lactiflora(Organic Chemistry)
• Nuclear factor-κB dependency of doxorubicin sensitivity in gastric cancer cells is determined by manganese superoxide dismutase expression
• Chemical vapor infiltration (CVI) SiC whisker on carbon woven fabric for filter applications
• Various Patterns of Repigmentation after Narrowband UVB Monotherapy in Patients with Vitiligo
• Sequential Development of Herpes Zoster Duplex Unilateralis during Oral Famciclovir Treatment
• Synthesis of Phosphatidylserine in Carrot Cells Cultured under Carbon-Source Starvation
• A RFID EPC C1 Gen2 System with Channel Coding Capability in AWGN Noise Environments
• Study on lon-Exchange Behavior of Cu-CN Complexes
• Residual fraction as a parameter to predict bladder outlet obstruction in men with lower urinary tract symptoms
• Effects of Brimonidine 0.2%-Timolol 0.5% Fixed-Combination Therapy for Glaucoma
• Changes of precore nucleic acid sequence in chronic hepatitis B patients with and without interferon administration
• Protein tyrosine phosphatase and redox regulation in vascular neointima formation(Special lecture,53^ Annual Meeting of the Japan Society of Smooth Muscle Research Program and Abstracts)
• Analysis of Plantar Foot Pressure during the Non-crutch, Two-point, and Four-point Crutch Gait performed by Healthy Volunteers
• MC-27 AERODYNAMICALLY INDUCED POWER LOSS IN HARD DISK DRIVES
• Atomic Layer Etching of Si(100) at Room Temperature
• Atomic Layer Etching of Si(100) at Room Temperature
• Epigenetic methylation and expression of caspase 8 and survivin in hepatocellular carcinoma
• The Effects of Symmetrical Self-performed Facial Muscle Exercises on the Neuromuscular Facilitation of Patients with Facial Palsy
• Simple Oblique Lumbar Magnetic Resonance Imaging Technique and its Diagnostic Value for Extraforaminal Disc Herniation
• Magnetic and Structural Phase Transitions of EuFe2As2 Studied via Neutron and Resonant X-ray Scattering
• Temporal Changes in Pain and Sensory Threshold of Geriatric Patients after Moist Heat Treatment
• Protein Tyrosine Phosphatase SHP-2 Is Positively Involved in Platelet-Derived Growth Factor-Signaling in Vascular Neointima Formation via the Reactive Oxygen Species-Related Pathway
• The Effects of Functional Electrical Stimulation on Balance of Stroke Patients in the Standing Posture
• Blockade of K+ and Ca2+ Channels by Azole Antifungal Agents in Neonatal Rat Ventricular Myocytes
• The Effect of an Early Lumbar Exercise Program on Trunk Strength and the Oswestry Disability Index after Herniated Nucleus Pulposus Surgery
• Configuration Dependency of Attached Epoxy Groups on Graphene Oxide Reduction: A Molecular Dynamics Simulation
• Endothelin-1 Induces Contraction via a Syk-Mediated p38 Mitogen-Activated Protein Kinase Pathway in Rat Aortic Smooth Muscle
• Binding Evaluation of Targeted Microbubbles with Biotin–Avidin Interaction by Surface Plasmon Resonance Biosensor
• Oxygen Vacancy Chain Formation in TiO2 under External Strain for Resistive Switching Memory
• Water Trapping at the Graphene/Al
• Inverted Bottom-Emission Polymer Light-Emitting Devices Doped with Organic Salt
• Silk Peptide Intake Increases Fat Oxidation at Rest in Exercised Mice
• Noxiousness of Hypertension-related Norepinephrine and Upregulation of Norepinephrine Induced by High Intensity Electrical Stimulation in Healthy Volunteers
• Change of Muscular Activity and Dynamic Stability of the Knee Joint Due to Excessive and Repetitive Jumping or Cutting by Female Athletes
• Water Trapping at the Graphene/Al₂O₃ Interface (Special Issue : Microprocesses and Nanotechnology)
• Effect of Organic Salt Doping on Electron Injection in Single-Layer Polymer Light-Emitting Diodes
• Screen-Printed Polymer:Fullerene Bulk-Heterojunction Solar Cells
• Temporal Changes in Skin Temperature Caused by Wet and Dry Heat in Healthy Volunteers
• The Effect of Standing Posture-enhancing Exercise on Parkinson's Disease Patients' Turning Around Motion
• A model for steam bubble formation at a submerged orifice in a flowing liquid.
• A Pilot Study on Pain and the Upregulation of Myoglobin through Low-frequency and High-amplitude Electrical Stimulation-induced Muscle Contraction
• The proportion of uniparental disomy is increased in Prader-Willi syndrome due to an advanced maternal childbearing age in Korea

もっと見る 閉じる

スポンサーリンク