c-Jun N-terminal Kinase Contributes to Norepinephrine-Induced Contraction Through Phosphorylation of Caldesmon in Rat Aortic Smooth Muscle
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概要
- 論文の詳細を見る
Vascular smooth muscle contraction is mediated by activation of extracellular signal-regulated kinase (ERK) 1/2, an isoform of mitogen-activated protein kinase (MAPK). However, the role of stress-activated protein kinase/c-Jun N-terminal kinase (JNK) in vascular smooth muscle contraction has not been defined. We investigated the role of JNK in the contractile response to norepinephrine (NE) in rat aortic smooth muscle. NE evoked contraction in a dose-dependent manner, and this effect was inhibited by the JNK inhibitor SP600125. NE increased the phosphorylation of JNK, which was greater in aortic smooth muscle from hypertensive rats than from normotensive rats. NE-induced JNK phosphorylation was significantly inhibited by SP600125 and the conventional-type PKC (cPKC) inhibitor Gö6976, but not by the Rho kinase inhibitor Y27632 or the phosphatidylinositol 3-kinase inhibitor LY294002. Thymeleatoxin, a selective activator of cPKC, increased JNK phosphorylation, which was inhibited by Gö6976. SP600125 attenuated the phosphorylation of caldesmon, an actin-binding protein whose phosphorylation is increased by NE. These results show that JNK contributes to NE-mediated contraction through phosphorylation of caldesmon in rat aortic smooth muscle, and that this effect is regulated by the PKC pathway, especially cPKC.
- 社団法人 日本薬理学会の論文
- 2006-02-20
著者
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Park Hyo-jun
韓国
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Lee Chang
Department Of Physiology & Immunology School Of Medicine Konkuk University
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LEE Yun
Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine
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Kim Hyo
Departments Of Physiology College Of Medicine Konkuk University
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Lee Chang-kwon
Department Of Physiology & Immunology School Of Medicine Konkuk University
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Min Kyung
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Tohoku University
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Kim Bokyung
Department Of Physiology & Immunology School Of Medicine Konkuk University
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Kim B.
韓国
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Kim Bokyung
College Of Medicine Konkuk University
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Kim Bokyung
Department Of Physiology College Of Medicine Institute Of Biomedical Science And Technology Konkuk U
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LEE Keun
Department of Prosthodontics, College of Dentistry, Yonsei University
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Lee Keun
Department Of Medicine College Of Medicine Konkuk University
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Lee Yun
Department Of Applied Chemistry Saga University
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Lee Chang-kwon
Department Of Biotechnology Graduate School Of Engineering Osaka University
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Kim Jin-hyun
Department Of Veterinary Pathology College Of Veterinary Medicine And Agricultural Biotechnology Seo
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KIM Junghwan
Department of Physical Therapy, College of Natural Science, Yongin University
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PARK Hyo-Jun
Departments of Physiology, College of Medicine, Konkuk University
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LEE Youn
Department of Physiology, College of Medicine, Institute of Biomedical Science and Technology, Konku
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KIM Hyojin
Department of Physiology, College of Medicine, Institute of Biomedical Science and Technology, Konku
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KIM Jaeheung
Department of Physiology, College of Medicine, Institute of Biomedical Science and Technology, Konku
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Lee Youn
Department Of Physiology College Of Medicine Institute Of Biomedical Science And Technology Konkuk U
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Kim Bokyung
韓国
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Kim Junghwan
Department Of Physiology & Immunology School Of Medicine Konkuk University
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Kim Junghwan
Department Of Physical Therapy College Of Natural Science Yongin University
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Kim Bongtae
Department Of Veterinary Pathology College Of Veterinary Medicine And School Of Agicultural Biotechn
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Lee Yun
Department Of Physiology College Of Medicine Hallym University
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Kim J.
Department Of Physiology & Immunology School Of Medicine Konkuk University
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Lee Youn
Department Of Hospital Pathology St. Mary's Hospital The Catholic University Of Korea College O
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Kim Junghwan
Dep. Of Physical Therapy Coll. Of Public Health & Welfare Yongin Univ.
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Min Kyung
Department Of Physical Therapy College Of Natural Science Yongin University
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LEE Yun
Department of Physiology, College of Medicine, Hallym University
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Lee Keun
Department of Materials Engineering, Yonsei University, Seoul 120-749, Republic of Korea
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KIM Hyojin
Department of Bioenergy Science and Technology, Chonnam National University
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LEE Keun
Department of Materials Engineering, Yonsei University
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KIM Bokyung
Department of Medicine, Konkuk University
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Lee Keun
Department of Bioengineering and Technology, Kangwon National University
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