PROINFLAMMATORY ACTIVITY OF COLCHICINE AS REVEALED IN RAT PAW EDEMA METHOD
スポンサーリンク
概要
- 論文の詳細を見る
Colchicine, a microtubles-disrupting agent, when injected into subplantar region of the hind paw of rats, provoked an immediate elevation of the permeability of local vascular networks, resulting in a local tissue edema. The extent of the edema was dose-dependent. It was not affected at all by pretreatment of the rats with cyproheptadine, while cyproheptadine almost completely blocked formation of serotonin edema. When colchicine was applied together with serotonin, a synergistic enhancement of edema formation was observed. Colchicine and histamine were also synergistic.
- 公益社団法人日本薬学会の論文
著者
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Min Kyung
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Tohoku University
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Tsurufuji Susumu
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Tohoku University
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MIZUNO CHIKAKO
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tohoku University
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Mizuno Chikako
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Tohoku University
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