PROTEINASE INHIBITORS SUPPRESS THE FORMATION OF GRANULATION TISSUE IN THE CARRAGEENIN-INDUCED INFLAMMATION IN RATS
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概要
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Effect of proteinase inhibitors on the carrageenin-induced inflammation was studied. The formation of granulation tissue was markedly inhibited by a single injection of ε-amino-n-caproic acid n-hexyl ester (EACA hexyl ester, 300 mg/kg) into the carrageenin-air-pouch immediately after carrageenin injection, whereas repeated injections of the inhibitor starting at 12 hr, 24 hr and 48 hr after carrageenin injection were less effective, slightly effective and ineffective, respectively. A dose-dependent inhibition of both the formation of granulation tissue and the migration of polymorphonuclear leukocytes (PMNs) into the inflammatory locus was found by a single injection of EACA hexyl ester into the carrageenin-air-pouch immediately after carrageenin injection. Similarly, a single injection of L-1-tosylamide-2-phenylethyl chloromethyl ketone (TPCK, 50 mg/kg) and N-α-p-tosyl-L-lysine chloromethyl ketone (TLCK, 30 mg/kg) inhibited both the formation of granulation tissue and the migration of PMNs into the inflammatory locus. These results suggest that serine proteinase inhibitors such as EACA hexyl ester, TPCK and TLCK exert their anti-inflammatory actions by interfering with the initial inflammatory reactions including the migration of PMNs into inflammatory locus after carrageenin injection.
- 公益社団法人日本薬学会の論文
著者
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WATANABE Kazuyoshi
Department of Pediatrics, Nagoya University
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NAKAGAWA Hideo
Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharma
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SHUTO KATSURO
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tohoku University
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ISAJI MASAYUKI
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tohoku University
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TSURUFUJI SUSUMU
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tohoku University
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Nakagawa Hideo
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University:institute Of Cytosig
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Nakagawa H
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Nakagawa Hideo
Department Of Physiological Chemistry Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmace
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Isaji Masayuki
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Tohoku University
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Tsurufuji S
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Tohoku University:institute Of Cytosig
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Tsurufuji Susumu
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University:institute Of Cytosig
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Tsurufuji Susumu
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Tohoku University
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Watanabe Kazuyoshi
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University:institute Of Cytosig
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Shuto Katsuro
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Tohoku University
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Watanabe K
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Watanabe K
Kureha Biomedical Research Lab. Tokyo Jpn
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Nakagawa Hideo
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Tohoku University
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Watanabe Kazuyoshi
Department Of General Medicine Juntendo University School Of Medicine
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WATANABE Kazuyoshi
Department of Biochemistry Faculty of Phrmaceutical Sciences, Toyama Medical and Pharmaceutical University
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