Effects of Cytokine-Induced Neutrophil Chemoattractants (CINCs) on Shape Change, Adhesiveness and Phagocytosis of Rat Neutrophils
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概要
- 論文の詳細を見る
Rat cytokine-induced neutrophil chemoattractants (CINC)-1,-2α, -2β and -3 belong to α-chemokines and are known to be potent chemoattractants for rat neutrophils in vivo and in vitro. In this study, the abilities of CINCs to affect several functions of rat neutrophils are estimated. All CINCs at a concentration of 10^<-8> M induced the polarization of rat neutrophils. The adhesion of each CINC-treated neutrophil to fibrinogen significantly increased, reaching a maximal adhesion at 10^<-8> M of each CINC. The CINCs enhanced the phagocytosis of heat-killed yeast cells by neutrophils in a dose-dependent manner. In contrast, CINCs did not induce the production of reactive nitrogen intermediates. The results suggest that CINCs play a significant role in neutrophil infiltration and phagocytosis at inflammatory sites in rats.
- 公益社団法人日本薬学会の論文
- 1997-08-15
著者
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Al-mokdad Maher
Department Of Physiological Chemistry Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmace
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Nakagawa H
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Nakagawa Hideo
Department Of Physiological Chemistry Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmace
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Shibata Futoshi
富山医科薬科大学 薬学部衛生物化
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Shibata Futoshi
Department Of Applied Chemistry Faculty Of Engineering Nagasaki University
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Nakagawa Hideo
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Tohoku University
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