Changes in the Levels of Rat Interleukin 8/CINC and Gelatinase in the Exudate of Carrageenin-Induced Inflammation in Rats
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概要
- 論文の詳細を見る
A sensitive enzyme-linked immunosorbent assay (ELISA) for rat interleukin 8/cytokine-induced neutrophil chemoattractant (CINC) has been established by using biotin-conjugated anti-CINC rabbit IgG. The biotin-streptavidin sandwich ELISA detected CINC at concentrations from 3 pg/ml up to 30 ng/ml. The concentration of CINC in the pouch fluid (exudate) of rat carrageenin-induced inflammation was measured by the ELISA. After a time lag of about 2 h, neutrophils steadily accumulated in the carrageenin/air-pouch until 8 h. Similarly, the CINC level of exudate increased after about a 2-h lag, and reached a maximum (134 ng/ml) at 8 h, and thereafter decreased to a negligible concentration at 24 h after carrageenin injection. In association with the rise in CINC level, the concentration of exudate 96-kDa gelatinase corresponding to neutrophil gelatinase/type IV collagenase increased with time. The results suggest that CINC contributes, at least in part, to the neutrophil migration into the inflammatory lesion of the carrageenin-induced inflammation in rats
- 公益社団法人日本薬学会の論文
著者
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WATANABE Kazuyoshi
Faculty of Medical Welfare, Aichi Shukutoku University
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Nakagawa Hideo
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University:institute Of Cytosig
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Nakagawa H
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Tsurufuji S
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Tohoku University:institute Of Cytosig
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Tsurufuji Susumu
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University:institute Of Cytosig
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IKESUE Atsutoshi
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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KATO Hideko
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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DEBUCHI Hayami
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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NAGANAWA Masayuki
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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MITAMURA Mari
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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Kato H
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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Debuchi H
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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Mitamura M
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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Watanabe Kazuyoshi
Faculty Of Medical Welfare Aichi Shukutoku University
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Watanabe Kazuyoshi
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University:institute Of Cytosig
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Kato Hideko
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University:institute Of Cytosig
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Mitamura Mari
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University:institute Of Cytosig
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Debuchi Hayami
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University:institute Of Cytosig
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Watanabe K
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Watanabe K
Kureha Biomedical Research Lab. Tokyo Jpn
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Ikesue A
Hisamitsu Pharmaceutical Co. Inc. Ibaraki Jpn
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Naganawa Masayuki
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University:institute Of Cytosig
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Nakagawa Hideo
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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