EFFECT OF PROTEINASE INHIBITORS HAVING ANTIINFLAMMATORY ACTIVITY ON GELATINASE, ELASTASE AND CATHEPSIN G ISOLATED FROM RAT POLYMORPHONUCLEAR LEUKOCYTES

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概要

• 論文の詳細を見る

• Gelatinase, elastase and cathepsin G isolated from the granule extract of rat polymorphonuclear leukocytes (PMNs) had similar properties to the enzymes of human PMNs already reported. Effect of proteinase inhibitors on these neutral proteinases isolated from rat PMNs was studied. ε-Amino-n-caproic acid n-hexyl ester, a proteinase inhibitor having anti-inflammatory activity, inhibited cathepsin G, whereas elastase was activated by the inhibitor. On the other hand, leupeptin, L-1-tosylamide-2-phenylethyl chloromethyl ketone and N-a-p-tosyl-L-lysine chloromethyl ketone, which had been reported as antiinflammatory inhibitors, had no inhibitory effect on these neutral proteinases. These results suggest that proteinase inhibitors reported as anti-inflammatory agents exert their anti-inflammatory actions not by direct inhibition of the neutral proteinases released from PMNs, but by other effects such as suppression of the infiltration of PMNs into inflammatory locus.

• 公益社団法人日本薬学会の論文

著者

• SUZUKI Miwako

  Department of Resources and Environment Science, School of Humanities and Culture, Tokai University

• WATANABE Kazuyoshi

  Department of Pediatrics, Nagoya University

• Suzuki Miwako

  Department Of Biochemistry Faculty Of Pharmaceutical Sciences Tohoku University

• NAKAGAWA Hideo

  Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharma

• SHUTO KATSURO

  Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tohoku University

• IWATA KUMIKO

  Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tohoku University

• ISAJI MASAYUKI

  Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tohoku University

• TSURUFUJI SUSUMU

  Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tohoku University

• Nakagawa Hideo

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University:institute Of Cytosig

• Nakagawa H

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Nakagawa Hideo

  Department Of Physiological Chemistry Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmace

• Isaji Masayuki

  Department Of Biochemistry Faculty Of Pharmaceutical Sciences Tohoku University

• Tsurufuji S

  Department Of Biochemistry Faculty Of Pharmaceutical Sciences Tohoku University:institute Of Cytosig

• Tsurufuji Susumu

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University:institute Of Cytosig

• Tsurufuji Susumu

  Department Of Biochemistry Faculty Of Pharmaceutical Sciences Tohoku University

• Watanabe Kazuyoshi

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University:institute Of Cytosig

• Iwata Kumiko

  Department Of Biochemistry Faculty Of Pharmaceutical Sciences Tohoku University

• Shuto Katsuro

  Department Of Biochemistry Faculty Of Pharmaceutical Sciences Tohoku University

• Watanabe K

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Watanabe K

  Kureha Biomedical Research Lab. Tokyo Jpn

• Nakagawa Hideo

  Department Of Biochemistry Faculty Of Pharmaceutical Sciences Tohoku University

• Watanabe Kazuyoshi

  Department Of General Medicine Juntendo University School Of Medicine

• WATANABE Kazuyoshi

  Department of Biochemistry Faculty of Phrmaceutical Sciences, Toyama Medical and Pharmaceutical University

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