INHIBITION OF ALLERGIC FOOTPAD INFLAMMATION BY ANTIRHEUMATIC DRUG D-PENICILLAMINE
スポンサーリンク
概要
- 論文の詳細を見る
An allergic footpad inflammation of mice was induced by using azobenzenearsonateacetyl bovine serum albumin conjugate as an antigen. Sensitization was made with the aid of Freund's complete adjuvant and the allergic reaction was elicited by using an emulsion consisting of Freund's incomplete adjuvant and 0.9% NaCl solution as a carrier of the challenging antigen. Allergic footpad swelling reached a maximum 24 hr after the challenge dose. D-Penicillamine, an anti-rheumatic drug, exerted a strong inhibitory effect on the allergic process, if animals were treated with this drug for 21 days at a dose of 600 mg/kg/day.
- 公益社団法人日本薬学会の論文
著者
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OHUCHI Kazuo
Department of Orthopaedics, Fukushima Medical University
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TSURUFUJI SUSUMU
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tohoku University
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Ohuchi Kazuo
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Tohoku University
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Tsurufuji Susumu
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Tohoku University
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ISHIGURO MASAMICHI
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tohoku University
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MIURA MARIKO
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tohoku University
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ISHIGURO Masatsune
Department of Biochemistry, School of Clinical Pharmaceutical Sciences, Nagasaki University
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Miura Mariko
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Tohoku University
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Ishiguro Masamichi
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Tohoku University
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OHUCHI KAZUO
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tohoku University
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OHUCHI Kazuo
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tohoku University:Institute of Cytosignal Research Inc.:College of Medical Science, Tohoku University
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