EFFECT OF METHYLPREDNISOLONE AND "PULSE" THERAPY WITH METHYLPREDNISOLONE SODIUM SUCCINATE ON AUTOLOGOUS IMMUNE COMPLEX NEPHRITIS IN RATS
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概要
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Autologous immune complex (AIC) nephritis was induced in rats with a single footpad injection of renal tubular epithelial antigen suspended in complete Freund's adjuvant. It was suggested by gel filtration of serum on Sephadex G-200 column that increase in the concentration of macroglobulins was the first alteration reflected on the serum proteins after immunization ; the concentration of macroglobulins increased while the concentrations of albumin and γ-globulin still remained in the normal range. The effect of 6α-methylprednisolone sodium succinate (MP-S), 6α-methylprednisolone (MP) and cyclophosphamide on the AIC nephritis in rats was studied. "Pulse" therapy, that is, an intraperitoneal administration of a large dose (26.5 mg/kg) of MP-S for 3 successive days a week and followed by an intermission for 4 days a week was started from the week of immunization with renal tubular epithelial antigen and continued for 8 weeks, resulting in the retardation of the AIC nephritis induction associated with a partial suppression of the development of proteinuria. Treatment with MP (4 mg/kg) or cyclophosphamide (10 mg/kg) every other day from the week of immunization for 8 weeks partially retarded or completely suppressed the AIC nephritis induction, respectively. On the other hand, the MP-S "Pulse" therapy and the MP treatment of rats suffering from the already established AIC nephritis resulted in no apparent improvement of the disease.
- 公益社団法人日本薬学会の論文
著者
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Nakagawa Hideo
Department Of Physiological Chemistry Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmace
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Tsurufuji Susumu
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Tohoku University
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SAGAE YOSHIYUKI
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tohoku University
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TOMABECHI NORIKO
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tohoku University
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OIKAWA SUMIKO
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tohoku University
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Oikawa Sumiko
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Tohoku University
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Sagae Yoshiyuki
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Tohoku University
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Nakagawa Hideo
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Tohoku University
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Tomabechi Noriko
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Tohoku University
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