Chemokine Receptor CXCR2 Activates Distinct Pathways for Chemotaxis and Calcium Mobilization
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概要
- 論文の詳細を見る
Rat cytokine-induced neutrophil chemoattractant-3 (CINC-3) has neutrophil chemotactic activity compara-ble with that of CINC-1 and CINC-2, but induces calcium mobilization more potently than CINC-1 and CINC-2. However, only one CINC receptor, CXCR2, has been found in rat neutrophils. Therefore we attempted to determine the biochemical basis for the differences in neutrophil responses to CINC-1/-2 versus CINC-3. Both chemotactic activity and calcium mobilization induced by CINC-3 were desensitized by a 100-fold excess of CINC-1, which was consistent with our previous results showing that CINC-1 has 70-fold lower affinity to the receptor on rat neutrophils than CINC-3. Desensitization appeares to be reflected by the affinity of the ligands to the receptor. CINC-1- and CINC-3-induced chemotaxis was sensitive to inhibition by pertussis toxin, whereas calcium mobilization induced by CINC-1 and CINC-3 was insensitive. These results suggest that CINCs induce neutrophil chemotaxis and calcium mobilization through distinct G-proteins with different efficiency.
- 公益社団法人日本薬学会の論文
- 2002-09-01
著者
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NAKAGAWA Hideo
Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharma
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Nakagawa Hideo
Department Of Physiological Chemistry Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmace
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KONISHI Kiyoshi
Department of Biochemistry, Toyama Medical and Pharmaceutical University Faculty of Medicine
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Konishi Kiyoshi
Department Of Microbiology Nippon Dental University
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SHIBATA Futoshi
Department of Applied Chemistry, Faculty of Engineering, Nagasaki University
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Shibata Futoshi
富山医科薬科大学 薬学部衛生物化
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Shibata Futoshi
Department Of Applied Chemistry Faculty Of Engineering Nagasaki University
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Nakagawa Hideo
Department Of Physiological Chemistry Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmace
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Nakagawa Hideo
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Tohoku University
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