ANTI-INFLAMMATORY EFFECT OF A SELECTIVE INHIBITOR OF ELASTASE, CATHEPSIN G AND CHYMOTRYPSIN ON CARRAGEENIN-INDUCED INFLAMMATION IN RATS

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概要

• 論文の詳細を見る

• The anti-inflammatory activity of a proteinase inhibitor on carrageenin-induced inflammation was studied by using N-(2,4-dinitrophenyl)-benzisothiazolinone-1,1-dioxide, a selective inhibitor of elastase, cathepsin G and chymotrypsin. The selective inhibitor suppressed leukocyte chemotaxis in vivo and in vitro, vascular permeability and development of granulation tissue. These results suggest that a selective inhibitor of elastase, cathepsin G and chymotrypsin is an effective agent for suppression of induction and development of carrageenin-induced inflammation in rats.

• 公益社団法人日本薬学会の論文

著者

• WATANABE Kazuyoshi

  Department of Pediatrics, Nagoya University

• NAKAGAWA Hideo

  Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharma

• Sato K

  Toyama Medical And Pharmaceutical Univ. Toyama Jpn

• Nakagawa Hideo

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University:institute Of Cytosig

• Nakagawa H

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Nakagawa Hideo

  Department Of Physiological Chemistry Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmace

• Tsurufuji S

  Department Of Biochemistry Faculty Of Pharmaceutical Sciences Tohoku University:institute Of Cytosig

• Tsurufuji Susumu

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University:institute Of Cytosig

• KANEKO MASAYUKI

  Tohoku University

• SATO KIYOYUKI

  Department of Biochemistry, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical Un

• TSURUFUJI SUSUMU

  Tohoku University

• Watanabe Kazuyoshi

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University:institute Of Cytosig

• Watanabe K

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Watanabe K

  Kureha Biomedical Research Lab. Tokyo Jpn

• Nakagawa Hideo

  Department Of Biochemistry Faculty Of Pharmaceutical Sciences Tohoku University

• Watanabe Kazuyoshi

  Department Of General Medicine Juntendo University School Of Medicine

• WATANABE Kazuyoshi

  Department of Biochemistry Faculty of Phrmaceutical Sciences, Toyama Medical and Pharmaceutical University

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