HOST-MEDIATED ANTITUMOR EFFECT OF GRIFOLAN NMF-5N, A POLYSACCHARIDE OBTAINED FROM GRIFOLA FRONDOSA

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概要

• 論文の詳細を見る

• The antitumor mechanism of grifolan NMF-5N, a β-1,3-glucan obtained from mycelia of Grifola frondosa, was examined. Grifolan NMF-5N did not show direct cytocidal effect on cultured tumor cells. However, intraperitoncal injection of grifolan NMF-5N increased the number of peritoneal exudate cells and peritoneal adherent cells which showed cytostatic activity towards syngeneic tumor cells. In an in vivo assay, the administration of carrageenan, an inhibitor of macrophage function, reduced the antitumor activity of grifolan NMF-5N. The delayed-type hypersensitivity reaction was augmented in the grifolan NMF-5N-administered mice. The administration of NMF-5N augmented the induction of cytotoxic T cells but the antitumor activity of grifolan NMF-5N was reduced in athymic nu/nu mice. In addition, the treatment with anti-Thy 1,2 antibody and complement C' of spleen cells taken from mice which showed regression of tumor due to grifolan NMF-5N, reduced the neutralizing effect in Winn assay. These results suggested that grifolan NMF-5N shows antitumor activity via hostmediated mechanisms and both macrophages and T cells play important roles in the mechanisms.

• 社団法人日本薬学会の論文

著者

• OHNO NAOHITO

  Tokyo College of Pharmacy

• Ohno Naohito

  東京薬科大学 免疫学

• Ohno Naohito

  Lab. For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo Univ. Of Pharmacy And Lif

• YADOMAE Toshiro

  Tokyo University of Pharmacy and Life Science, School of Pharmacy

• SUZUKI IWAO

  Tokyo College of Pharmacy

• OIKAWA Shozo

  Tokyo College of Pharmacy

• Ohno Naohito

  Laboratory Of Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharma

• Ohno Naohito

  Laboratory For Immunopharmacology Of Microbial Products Tokyo University Of Pharmacy And Life Scienc

• OHSAWA Masumi

  Tokyo College of Pharmacy

• TAKEYAMA Takahiro

  Tokyo College of Pharmacy

• SATO Kichiro

  Tokyo College of Pharmacy

• Oikawa S

  Nippon Beet Sugar Mfg. Co. Ltd. Tokyo Jpn

• Sato K

  Toyama Medical And Pharmaceutical Univ. Toyama Jpn

• Ohsawa M

  Nippon Beet Sugar Mfg. Co. Ltd. Tokyo Jpn

• Suzuki Iwao

  Faculty Of Pharmaceutical Sciences Tohoku University

• Yadomae T

  Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm

• Yadomae Toshiro

  Tokyo College Of Pharmacy

• Takeyama Takahiro

  Tokyo College Of Pharmacy:nippon Beet Sugar Mfg. Co. Ltd.

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