Effect of β-Glucans on the Nitric Oxide Synthesis by Peritoneal Macrophage in Mice
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概要
- 論文の詳細を見る
Nitric oxide (NO) is an important effector molecule on antimicrobial and antitumor effects of macrophages. (1→3)-β-D-Glucan (β-glucan) is well known to show various immunopharmacological effects such as antimicrobial effect and antitumor effect by activating various points of host defense mechanisms. This paper deals with NO synthetic activity or peritoneal macrophage (PM) induced by β-glucan administration in mice. The activity was determined by measuring NO concenration in PM culture by Griess reagent after 24 or 48h in vitro culture. Administration (i.p. or i.v.) of a branched soluble (1→3)-β-D-glucan, grifolan (GRN), from Grifola frondosa enhanced NO synthesis of PM dose and time dependently. The activity was abrogated by the addition of N^G-monomethyl-L-arginine (L-NMMA) in vitro. The most significant activity was observed at 3-7d after the administration of GRN (250 μg/mouse). PM from all strains of ICR, C3H/HeN, C3H/HeJ, BALB/c, BALB/c nu/nu, C57BL, and AKR mice showed significant activity by GRN administration. Among β-glucans tested, SSG and OL-2,highly branched soluble glucans, and a particulate β-glucan, zymosan, showed similar activity. Addition of GRN directly to in vitro RAW 264.7 or proteose peptone induced peritoneal macrophage (PP-PEC) cultue could not enhance NO synthesis. However, NO synthesis of PP-PEC was enhanced in vitro by addition of GRN in the presence of interferon γ (IFNγ). Gene expression of IFNγ mRNA in the liver and PEC were enhanced in GRN administered mice assessed by reverse transcriptase assisted PCR (RT-PCR) method. These facts strongly suggested that β-glucan has capacity to enhance NO synthesis of PM in vivo through IFNγ mediated mechanism.
- 公益社団法人日本薬学会の論文
- 1996-04-15
著者
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橋本 忠
北陸大・薬
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Ohno Naohito
東京薬科大学 免疫学
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Ohno Naohito
東京薬科大学 薬 微生物
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Ohno N
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Adachi Yoshiyuki
東京薬科大学 免疫学
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Adachi Y
Tokyo Univ. Pharmacy And Life Sci. Tokyo Jpn
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Adachi Yoshiyuki
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Ohno Naohito
Laboratory Of Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharma
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Ohno Naohito
Laboratory For Immunopharmacology Of Microbial Products Tokyo University Of Pharmacy And Life Scienc
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Ohno Naohito
School Of Pharmacy Tokkyo University Of Pharmacy And Life Science
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YADOMAE Toshiro
School of Pharmacy, Tokyo University of Pharmacy and Life Science
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EGAWA Yasushi
School of Pharmacy, Tokyo University Pharmacy and Life Science
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HASHIMOTO Tomoe
School of Pharmacy, Tokyo University Pharmacy and Life Science
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ADACHI Yoshiyuki
School of Pharmacy, Tokyo University Pharmacy and Life Science
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Hashimoto T
Hokuriku Univ. Kanazawa Jpn
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Egawa Yasushi
School Of Pharmacy Tokyo University Pharmacy And Life Science
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Hashimoto Toshihiro
Fac. Of Pharmaceutical Sciences Tokushima Bunri Univ.
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Yadomae T
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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