URETHANE TYPE PROTECTING GROUPS FOR CARBOXAMIDE IN PEPTIDE CHEMISTRY
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概要
- 論文の詳細を見る
Novel L-asparagine and L-glutamine derivatives with the carboxamide nitrogen (N^<ca>) acylated by urethane type protecting groups, tert-butyloxycarbonyl (Boc) and 4-nitrobenzyloxycarbonyl [Z(NO_2)], were synthesized through ruthenium tetroxide oxidative transformation of N^α, N^ω-diacylated L-2,4-diaminobutyric acid and L-ornithine. N^<ca>-Boc and N^<ca>-Z (NO_2) groups can be deprotected by trifluoroacetic acid and catalytic hydrogenation respectively. N^α, N^<ca>-DiBoc-Asn-OH is applied to peptide synthesis by dicyclohexylcarbodiimide or mixed anhydride method without nitrile formation.
- 社団法人日本薬学会の論文
- 1985-04-25
著者
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広瀬 恭子
Faculty of Pharmaceutical Sciences, Hokuriku University
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橋本 忠
北陸大・薬
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佐倉 直樹
北陸大・薬
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Sakura Naoki
Faculty Of Pharmaceutical Sciences Hokuriku University
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佐倉 直樹
School of Pharmacy, Hokuriku University
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橋本 忠
School of Pharmacy, Hokuriku University
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広瀬 恭子
School of Pharmacy, Hokuriku University
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Hashimoto T
Hokuriku Univ. Kanazawa Jpn
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Hashimoto Toshihiro
Fac. Of Pharmaceutical Sciences Tokushima Bunri Univ.
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広瀬 恭子
Faculty Of Pharmaceutical Sciences Hokuriku University
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橋本 忠
School Of Pharmacy Tokyo University Of Pharmacy And Life Sciences
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