Inhibition of Nitric Oxide Production in RAW 264.7 Cells by Azaphilones from Xylariaceous Fungi(Molecular and Cell Biology)

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概要

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• The aim of this study was to discover a novel agent that suppresses nitric oxide (NO) production stimulated by lipopolysaccharide (LPS) in RAW 264.7 cells. We carried out a screening test in fifteen azaphilone compounds, which were isolated from xylariaceous inedible mushrooms. The structure-activity relationship was discussed; accordingly, azaphilones were divided into five groups based on the functional groups attached to the main azaphilone backbone. Rubiginosin A, an azaphilone with an orsellinic acid moiety attached to the bicyclic azaphilone through an ester linkage, showed potential inhibitory activity. To clarify the mechanism involved, total RNA extraction, followed by RT-PCR for inducible nitric oxide synthase (iNOS) and finally electrophoresis on agarose gel were performed. These findings indicated that suppression of the LPS-induced NO production of rubiginosin A is due to the inhibition of iNOS protein synthesis.

• 公益社団法人日本薬学会の論文
• 2006-01-01

著者

• Hashimoto T

  Faculty Of Pharmaceutical Sciences Hokuriku University

• 橋本 忠

  北陸大・薬

• Quang Dang

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• 橋本 忠

  北陸大学薬学部

• SOMA Gen-Ichiro

  Institute for Health Sciences, Tokushima Bunri University

• HASHIMOTO Toshihiro

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• ASAKAWA Yoshinori

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• Asakawa Y

  Fac. Of Pharmaceutical Sciences Tokushima Bunri Univ.

• HARINANTENAINA Liva

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• NISHIZAWA Takashi

  Institute for Health and Sciences, Tokushima Bunri University

• KOHCHI Chie

  Institute for Health and Sciences, Tokushima Bunri University

• Nishizawa Takashi

  Institute For Health And Sciences Tokushima Bunri University

• Soma Gen-ichiro

  Institute For Health And Sciences Tokushima Bunri University

• Hashimoto Tadashi

  Faculty Of Pharmaceutical Sciences Hokuriku University

• Harinantenaina Liva

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Hashimoto T

  Hokuriku Univ. Kanazawa Jpn

• Kohchi Chie

  Institute For Health And Sciences Tokushima Bunri University

• Harinantenaina Liva

  Tokushima Bunri Univ. Tokushima Jpn

• Asakawa Y

  Tokushima Bunri Univ. Tokushima Jpn

• Asakawa Yoshinori

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Hashimoto Toshihiro

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Hashimoto Toshihiro

  Fac. Of Pharmaceutical Sciences Tokushima Bunri Univ.

• Hashimoto Tadashi

  Drug Metabolism Laboratories Drug Development Division Yamanouchi Pharmaceutical Co. Ltd.

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