Pregnane-Type Steroids from the Inedible Mushroom Thelephora terrestris

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概要

• 論文の詳細を見る

• Chromatographic fractionation of the methanol extract of fruiting bodies of the inedible Japanese mushroom Thelephora terrestris (Thelephoraceae) has led to the isolation and characterization of two unusual new pregnane-type steroids, 2β, 3α-dihydroxypregna-4, 7, 16-trien-12, 20-dione (2) and 1α, 2β, 3α-trihydroxypregna-4, 7, 16-trien-12, 20-dione (3) named terresterones A and B (2, 3), as well as the previously known compound stizophyllin, now assigned as 2β, 3α, 12β-trihydroxypregna-4, 7, 16-trien-20-one (1). Elucidation of their structures and the revision of the stereochemical assignment of stizophyllin were achieved by means of extensive 1D and 2D NMR, UV, CD, IR, MS and molecular modeling experiments. This paper presents the first report on the isolation of true pregnane-type steroids from the Fungi kingdom.

• 公益社団法人日本薬学会の論文
• 2005-03-01

著者

• 田中 正一

  Graduate School Of Pharmaceutical Sciences Kyushu University

• Hashimoto T

  Faculty Of Pharmaceutical Sciences Hokuriku University

• 橋本 忠

  北陸大・薬

• Quang Dang

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• 橋本 忠

  北陸大学薬学部

• HASHIMOTO Toshihiro

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• ASAKAWA Yoshinori

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• Asakawa Y

  Fac. Of Pharmaceutical Sciences Tokushima Bunri Univ.

• Tanaka Muneo

  Research Center Shiseido Ltd.

• Tanaka M

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• 田中 誠

  School Of Pharmaceutical Sciences Kitasato University

• RADULOVIC Niko

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• NUKADA Makiko

  Faculty of Food Culture, Kurashiki Sakuyo University

• TANAKA Masami

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• Hashimoto Tadashi

  Faculty Of Pharmaceutical Sciences Hokuriku University

• Hashimoto T

  Hokuriku Univ. Kanazawa Jpn

• Radulovic Niko

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University:department Of Chemistry Faculty Of Sci

• Asakawa Y

  Tokushima Bunri Univ. Tokushima Jpn

• Asakawa Yoshinori

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Hashimoto Toshihiro

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Hashimoto Toshihiro

  Fac. Of Pharmaceutical Sciences Tokushima Bunri Univ.

• Hashimoto Tadashi

  Drug Metabolism Laboratories Drug Development Division Yamanouchi Pharmaceutical Co. Ltd.

• Tanaka Masami

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

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