Studies on Cardiac Ingredients of Plants. XIII : Chemical Modification of Gitoxin to Cardiotonic Compounds without Vascular Contractile Effect

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概要

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• Nitrated gitoxins (4) and bufotoxin homologues with various lengths of alkyl chain at C-3 of the steroid nucleus (10) were prepared from gitoxin (1). The pharmacological activities of the resulting compounds (4 and 10) were evaluated by measurement of inhibitory effect on Na^+, K^+-adenosine triphosphatase (ATPase) prepared from dog kidney, positive inotropic effect (PIE) on isolated guinea-pig papillary muscle preparations, and the effect on smooth muscle using the mesenteric artery from spontaneously hypertensive rats. Most of the compounds showed a smaller contractile effect on the arterial muscle. Among these compounds, gitoxin 3''-nitrate (4g) exhibited the most desirable biological activities, such as PIE comparable to that of 1,1.25 times wider concentration-dependent range than 1,and lack of contractile activity on vascular muscle.

• 公益社団法人日本薬学会の論文
• 1997-04-15

著者

• 中村 康彦

  Department Of Formulation Research Dainippon Pharmaceutical Co. Ltd.

• Hashimoto T

  Faculty Of Pharmaceutical Sciences Hokuriku University

• 橋本 忠

  北陸大・薬

• HASHIMOTO Toshihiro

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• ASAKAWA Yoshinori

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• Asakawa Y

  Fac. Of Pharmaceutical Sciences Tokushima Bunri Univ.

• Nagatsu Akito

  Faculty Of Pharmaceutical Sciences Nagoya City University

• Ueda T

  Faculty Of Agriculture Saga University

• HOTTA Yoshihiro

  Department of Ophthalmology, Juntendo University School of Medicine

• Nagai S

  Hokuriku Univ. Kanazawa Jpn

• Nagai Shin-ichi

  Faculty Of Pharmaceutical Sciences Nagoya City University

• Takeya Kazumi

  Department of Pharmacology, Aichi Medical University

• Hotta Yoshihiro

  Hamamatsu Univ. Schol Of Medicine Hamamatsu Jpn

• Hotta Y

  Department Of Ophthalmology Juntendo University School Of Medicine

• Hotta Y

  Department Of Pharmacology Aichi Medical University

• Hotta Yoshihiro

  Department Of Ophthalmology Hamamatsu University School Of Medicine

• Shibatomi Kazutaka

  Faculty Of Pharmaceutical Sciences Nagoya City University

• Asano M

  Department Of Pharmacology Nagoya City University Medical School

• Asano Masahisa

  Department Of Pharmacology Nagoya City University Medical School

• HIDAKA Hiroyoshi

  Department of Pharmacology,Nagoya University School of Medicine

• SAKAKIBARA Jinsaku

  Faculty of Pharmacy, Meijo University

• Hidaka Hiroyoshi

  Department Of Pharmacology Nagoya University School Of Medicine

• Nakamura Yoshihide

  Technical Department Fuji Chemical Industries Co. Ltd.

• UEDA Taisei

  Faculty of Pharmaceutical Sciences, Nagoya City University

• NAKAMURA Yukitaka

  Faculty of Pharmaceutical Sciences, Nagoya City University

• TAKEMOTO Kouya

  Faculty of Pharmaceutical Sciences, Nagoya City University

• FUJITA Michiko

  Department of Pharmacology, Aichi Medical University

• Fujita Michiko

  Department Of Biochemistry And Applied Biosciences Faculty Of Agriculture Miyazaki University

• Fujita Michiko

  Department Of Pharmacology Aichi Medical University

• Takemoto K

  Faculty Of Pharmaceutical Sciences Nagoya City University

• Hashimoto T

  Hokuriku Univ. Kanazawa Jpn

• Takeya Kazumi

  Department Of Pharmacology Aichi Medical University

• Asakawa Y

  Tokushima Bunri Univ. Tokushima Jpn

• Asakawa Yoshinori

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Hashimoto Toshihiro

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Hashimoto Toshihiro

  Fac. Of Pharmaceutical Sciences Tokushima Bunri Univ.

• Nakamura Y

  Department Of Pharmacognosy Tohoku Pharmaceutical University

• Sakakibara J

  Faculty Of Pharmaceutical Sciences Nagoya City University

• Sakakibara Jinsaku

  Faculty Of Pharmaceutical Sciences Nagoya City University

• Hidaka H

  Department Of Pharmacology Nagoya University School Of Medicine

• Hidaka Hiroyoshi

  Department Of Pharmacology Mie University

• HIDAKA Hiroyoshi

  Department of Biochemistry, Institute for Developmental Research, Aichi Prefecture Colony

• Asano Masahisa

  Department of Pharmacolgy, Nagoya City University Medical School

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