HIGHLY SELECTIVE CLEAVAGE OF PYROGLUTAMYL-PEPTIDE BOND IN CONCENTRATED HYDROCHLORIC ACID
スポンサーリンク
概要
- 論文の詳細を見る
Highly selective cleavage reaction of pGlu-peptide bond is described. Two model peptides, pGlu-X-Ala-Phe-OH (X=Ile and Ser), and dog neuromedin U-8 (d-NMU-8) (1-7)-OH (pGlu-Phe-Leu-Phe-Arg-Pro-Arg-OH) were hydrolyzed in concentrated HCl at 0℃ for from 6 days to 6 weeks to give the predominant cleavage products of pGlu-X linkage of pGlu-X-Ala-Phe-OH and the pGlu-Phe linkage of d-NMU-8 (1-7)-OH, respectively. The ring-opening reaction of the pyrrolidone moiety of the pGlu residue occurred to a considerably lesser extent.
- 公益社団法人日本薬学会の論文
- 1996-04-15
著者
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OHKI Kazuhiro
Faculty of Pharmaceutical Sciences, Hokuriku University
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OKIMURA Keiko
Faculty of Pharmaceutical Sciences, Hokuriku University
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SAKURA Naoki
Faculty of Pharmaceutical Sciences, Hokuriku University
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HASHIMOTO Tadashi
Faculty of Pharmaceutical Sciences, Hokuriku University
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橋本 忠
北陸大・薬
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Ohnishi Kuniharu
Faculty Of Pharmaceutical Sciences Hokuriku University
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Ohnishi Kuniharu
北陸大学 薬学部
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Ohki K
Faculty Of Pharmaceutical Sciences Hokuriku University
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Ohki Kazuhiro
Faculty Of Pharmaceutical Sciences Hokuriku University
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Sakura N
Hokuriku Univ. Kanazawa Jpn
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Sakura Naoki
北陸大学 薬学部
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Sakura Naoki
Faculty Of Pharmaceutical Sciences Hokuriku University
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橋本 忠
北陸大学薬学部
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Hashimoto Tadashi
Faculty Of Pharmaceutical Sciences Hokuriku University
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Saito S
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
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Hashimoto T
Hokuriku Univ. Kanazawa Jpn
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SAITO Susumu
Faculty of Pharmaceutical Sciences, Hokuriku University
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Hashimoto Toshihiro
Fac. Of Pharmaceutical Sciences Tokushima Bunri Univ.
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