LTQ FT MS Accurate Mass and SRM Data Dependent Exclusion MSn Measurements for Structure Determination of FK228 and Its Metabolites (BMS特集号)

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概要

• 論文の詳細を見る

• MS2 fragments are produced by cleavage of all protonated molecules at the lone electron pairs of heteroatoms or the π electrons of double bonds of FK228. Usually, data dependent MS3 measurement cleaves only MS2 fragment of highest intensity that normally does not contain important metabolic sites. New SRM (selected reaction monitoring) data dependent exclusion MSn measurement makes it possible to obtain MS3 fragmentation data for all MS2 fragments, useful for structural determination of FK228 and its metabolites using ESI ion trap. The two different fragmentation pathways of FK228, of which fragment ions had the different elemental composition, were estimated. The accurate masses of FK228 fragment ions Fa1 (or Fb1) and Fa2 (or Fb2) were measured by LTQ FT MS to compare with those calculated exact masses. The fragmentation pathway of formers was correct as the result. LTQ FT MS accurate mass and SRM data dependent exclusion MSn measurements are required for the structure determination of FK228 and its metabolites.

• 日本質量分析学会の論文
• 2005-06-01

著者

• Kawamura A

  Pharmacokinetic Research Laboratories Fujisawa Pharmaceutical Co. Ltd.:(present Address)analysis And

• Hashimoto T

  Faculty Of Pharmaceutical Sciences Hokuriku University

• 橋本 忠

  北陸大・薬

• Shirage Toshifumi

  Departmnet Of Pharmacolinetics And Drug Metabolism Pharma Ceutical And Pharmacolinetic Research Labo

• Shiraga T

  Biopharmaceutical And Pharmacokinetic Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• 橋本 忠

  北陸大学薬学部

• TOZUKA Zenzaburo

  JCL Bioassay Corporation

• METELMANN STRUPAT

  Thermo Electron Co.

• SHIRAGA Toshifumi

  Fujisawa Pharmaceutical Co., Ltd.

• ISHIMURA Rika

  Fujisawa Pharmaceutical Co., Ltd.

• HASHIMOTO Tomoko

  Fujisawa Pharmaceutical Co., Ltd.

• KAWAMURA Akio

  Fujisawa Pharmaceutical Co., Ltd.

• KAGAYAMA Akira

  Fujisawa Pharmaceutical Co., Ltd.

• Tozuka Zenzaburo

  Biopharmaceutical And Pharmacokinetics Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Hashimoto Tadashi

  Faculty Of Pharmaceutical Sciences Hokuriku University

• Hashimoto T

  Hokuriku Univ. Kanazawa Jpn

• Ishimura Rika

  Fujisawa Pharmaceutical Co. Ltd.

• Kagayama Akira

  Fujisawa Pharmaceutical Co. Ltd.

• Shiraga Toshifumi

  Fujisawa Pharmaceutical Co. Ltd.

• Hashimoto Toshihiro

  Fac. Of Pharmaceutical Sciences Tokushima Bunri Univ.

• Kawamura Akio

  Department Of Surgery Sapporo Hokuyu Hospital Research Institute For Artificial Organs Transplantati

• Hashimoto Tadashi

  Drug Metabolism Laboratories Drug Development Division Yamanouchi Pharmaceutical Co. Ltd.

• Strupat Wolfgang

  Thermo Electron Co.

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