Tissue Distribution after Intravenous Dosing of Micafungin, an Antifungal Drug, to Rats(Biopharmacy)
スポンサーリンク
概要
- 論文の詳細を見る
The tissue distribution after an intravenous dose of micafungin (1 mg/kg), a new echinocandin-like lipopeptide antifungal agent, to male rats was investigated. Micafungin in plasma disappeared biexponentially with a terminal half-life of 5.03 h. Micafungin concentrations in liver, kidney, and lung at the first sampling time (5 min) after dosing were 1.15, 1.64, and 2.58-fold higher than the plasma concentration, and the AUC_<(0-∞) were 1.61, 3.42, and 2.89-fold higher than that for plasma. The terminal half-lives for these tissues were 5.14, 4.87, and 5.31 h, respectively, which were comparable to those for plasma. These results suggest that micafungin distributes rapidly and moderately into tissues such as the liver, kidney, and lungs, and that the concentrations in tissues decreased in parallel with the unchanged drug in plasma.
- 公益社団法人日本薬学会の論文
- 2004-07-01
著者
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Kawamura A
Pharmacokinetic Research Laboratories Fujisawa Pharmaceutical Co. Ltd.:(present Address)analysis And
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Niwa T
近畿大学 薬学部
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Takagi Akira
Post Marketing Product Development Astellas Pharma Inc.
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NIWA Toshiro
Post-marketing Development Research Center, Fujisawa Pharmaceutical Co., Ltd.
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TAKAGI Akira
Post-marketing Development Research Center, Fujisawa Pharmaceutical Co., Ltd.
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KAGAYAMA Akira
Biopharmaceutical and Pharmacokinetic Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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YOKOTA Yoshiko
Post-marketing Development Research Center, Fujisawa Pharmaceutical Co., Ltd.
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TOKUNAGA Akira
Post-marketing Development Research Center, Fujisawa Pharmaceutical Co., Ltd.
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YAMATO Yasuhiro
Biopharmaceutical and Pharmacokinetic Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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FUJIWARA Tomoichi
Fujisawa Technical Services Co., Ltd.
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HATAKEYAMA Junko
Fujisawa Technical Services Co., Ltd.
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ANEZAKI Masaharu
General Laboratory, BML, Inc.
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OHTSUKA Yuko
General Laboratory, BML, Inc.
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Ohtsuka Yuko
General Laboratory Bml Inc.
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Yokota Yoshiko
Post-marketing Development Research Center Fujisawa Pharmaceutical Co. Ltd.
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Yamato Yasuhiro
Biopharmaceutical And Pharmacokinetic Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Tokunaga Akira
Post-marketing Development Research Center Fujisawa Pharmaceutical Co. Ltd.
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Anezaki Masaharu
General Laboratory Bml Inc.
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Hatakeyama Junko
Fujisawa Technical Services Co. Ltd.
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Fujiwara Tomoichi
Fujisawa Technical Services Co. Ltd.
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Niwa T
Post-marketing Development Research Center Fujisawa Pharmaceutical Co. Ltd.
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Kagayama Akira
Biopharmaceutical And Pharmacokinetic Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Tokunaga Akira
First Department Of Surgery Nippon Medical School
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Niwa Toshiro
Post Marketing Product Development Astellas Pharma Inc.
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Kawamura Akio
Department Of Surgery Sapporo Hokuyu Hospital Research Institute For Artificial Organs Transplantati
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Ohtsuka Y
Department Of Microbiology Faculty Of Pharmaceutical Sciences Kyushu University
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