No Inhibition of Cytochrome P450 Activities in Human Liver Microsomes by Sulpiride, an Antipsychotic Drug(Biopharmacy)
スポンサーリンク
概要
- 論文の詳細を見る
The effects of sulpiride, an antipsychotic drug, on cytochrome P450 (CYP) activities in human liver microsomes were investigated. Sulpiride at 50 or 500 μM concentration neither inhibited nor stimulated CYP1A2-mediated 7-ethoxyresorufin O-deethylation, CYP2C9-mediated tolbutamide hydroxylation, CYP2C19-mediated S-mephenytoin 4'-hydroxylation, CYP2D6-mediated debrisoquine 4-hydroxylation, CYP2E1-mediated chlorzoxa-zone 6-hydroxylation, CYP3A4-mediated nifedipine oxidation, or CYP3A4-mediated testosterone 6β-hydroxylation. The free fractions of sulpiride in the incubation mixture estimated by ultracentrifugation were more than 90.5%. These results suggest that sulpiride would not cause clinically significant interactions with other drugs, which are metabolized by CYPs, via the inhibition of metabolism.
- 公益社団法人日本薬学会の論文
- 2005-01-01
著者
-
Shirage Toshifumi
Departmnet Of Pharmacolinetics And Drug Metabolism Pharma Ceutical And Pharmacolinetic Research Labo
-
Inoue-yamamoto Sachiko
アステラス製薬
-
Inoue Sachiko
Fujisawa Technical Services Co. Ltd.
-
Shiraga T
Biopharmaceutical And Pharmacokinetic Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
-
Niwa T
近畿大学 薬学部
-
Takagi Akira
Post Marketing Product Development Astellas Pharma Inc.
-
NIWA Toshiro
Post-marketing Development Research Center, Fujisawa Pharmaceutical Co., Ltd.
-
TAKAGI Akira
Post-marketing Development Research Center, Fujisawa Pharmaceutical Co., Ltd.
-
SHIRAGA Toshifumi
Biopharmaceutical and Pharmacokinetic Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
-
Tokunaga Akira
Post-marketing Development Research Center Fujisawa Pharmaceutical Co. Ltd.
-
Niwa T
Post-marketing Development Research Center Fujisawa Pharmaceutical Co. Ltd.
-
Tokunaga Akira
First Department Of Surgery Nippon Medical School
-
Shiraga Toshifumi
Biopharmaceutical And Pharmacokinetic Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
-
Niwa Toshiro
Post Marketing Product Development Astellas Pharma Inc.
関連論文
- Molecular Cloning, Expression, and Enzymatic Characterization of Rabbit Hydroxysteroid Sulfotransferase AST-RB2 (ST2A8)^1
- Molecular Cloning and Expression of an Amine Sulfotransferase cDNA: A New Gene Family of Cytosolic Sulfotransferases in Mammals^1
- Effect of Co-administration of Cationic Macromolecules on the In Vivo Disposition and situ Renal Disposition Characteristics of rhIL-11
- Hepatic Disposition Characteristics of Recombinant Human Interleukin-11 (rhIL-11) in the Perfused Rat Liver
- BLEEDING FROM FOVEOLAR HYPERPLASIA DEVELOPING ON A GASTROINTESTINAL STROMAL TUMOR OF THE STOMACH
- Effects of Serotonin-3 Receptor Antagonists on Cytochrome P450 Activities in Human Liver Microsomes(Biopharmacy)
- Contribution of Human Hepatic Cytochrome P450 Isoforms to the Metabolism of Psychotropic Drugs(Biopharmacy)
- Interindividual Variability in 5-Fluorouracil Metabolism and Procainamide N-Acetylation in Human Liver Cytosol(Biochemistry/Molecular Biology)
- LTQ FT MS Accurate Mass and SRM Data Dependent Exclusion MSn Measurements for Structure Determination of FK228 and Its Metabolites (BMS特集号)
- Identification of Cytochrome P450 Enzymes Involved in the Metabolism of FK228, a Potent Histone Deacetylase Inhibitor, in Human Liver Microsomes(Biopharmacy)
- Interindividual Variability in 2-Hydroxylation, 3-Sulfation, and 3-Glucuronidation of Ethynylestradiol in Human Liver(Biochemistry/Molecular Biology)
- Effect of Nilvadipine, a Dihydropyridine Calcium Antagonist, on Cytochrome P450 Activities in Human Hepatic Microsomes (Biochemistry/Molecular Biology)
- Effect of Cefixime and Cefdinir, Oral Cephalosporins, on Cytochrome P450 Activities in Human Hepatic Microsomes(Biochemistry/Molecular Biology)
- New SRM Data Dependent Exclusion (MS)^n Measurement for Structural Determination of Drug Metabolites Using LC/ESI/Ion Trap MS
- Stategy for Structure Elucidation of Drug Metabolites Derived from Protonated Molecules and (MS)^n Fragmentation of Zotepine, Tiaramide and their Metabolites
- Penetration and Absorption of Tacrolimus (FK506) Ointment in the Skin After a Single Dermal Application to the Rat
- Oxidative Metabolism of Tacrolimus and its Metabolite by Human Cytochrome P450 3A Subfamily
- Absorption, Distribution and Excretion of Tacrolimus (FK506) in the Baboon
- Absorption, Distribution, Metabolism and Excretion of Tacrolimus (FK506) in the Rat
- Comparison of Tacrolimus (FK506) Levels Determined by Three Different Methods in the Rat Blood
- Effect of Antifungal Drugs on Cytochrome P450 (CYP) 1A2, CYP2D6, and CYP2E1 Activities in Human Liver Microsomes(Biopharmacy)
- Effect of Antifungal Drugs on Cytochrome P450 (CYP) 2C9, CYP2C19, and CYP3A4 Activities in Human Liver Microsomes(Biopharmacy)
- No Inhibition of Cytochrome P450 Activities in Human Liver Microsomes by Sulpiride, an Antipsychotic Drug(Biopharmacy)
- Tissue Distribution after Intravenous Dosing of Micafungin, an Antifungal Drug, to Rats(Biopharmacy)
- Metabolism of Tacrolimus (FK506) and its Metabolite by Rat Liver Microsomes
- Cytotoxin Genes of Helicobacter pylori in Chronic Gastritis, Gastroduodenal Ulcer and Gastric Cancer: An Age and Gender Matched Case-Control Study
- Filling of Sub-μm Through-holes by Self-sputter Deposition
- Copper Self-Sputtering by Planar Magnetron
- Inhibition of Human Hepatic Cytochrome P450s and Steroidogenic CYP17 by Nonylphenol
- Metabolism and Interaction of Bisphenol A in Human Hepatic Cytochrome P450 and Steroidogenic CYP17
- Inhibition of Drug-Metabolizing Enzyme Activity in Human Hepatic Cytochrome P450s by Bisphenol A
- The Usefulness of Conducting Investigations on Intra-Abdominal Bacterial Contamination in Digestive Tract Operations
- (Pb, La)(Zr, Ti)O_3 Films by Multiple Electrophoretic Deposition / Sintering Processing : Thin Films
- Tacrolimus enhances colon anastomotic healing in rats
- Evidence for Singlet Oxygen Involvement in Rat and Human Cytochrome P450-dependent Substrate Oxidations
- Inflammation of the gastric remnant after gastrectomy : mucosal erythema is associated with bile reflux and inflammatory cellular infiltration is associated with Helicobacter pylori infection
- Simple and accurate ^C-urea breath test for detection of Helicobacter pylori in the remnant stomach after surgery
- The Presence of Tumor Necrosis Factor-α and its Antibody in the Sera of Cachexic Patients with Gastrointestinal Cancer
- Association of the interleukin-1 β genetic polymorphism and gastric cancer risk in Japanese
- Detection of Helicobacter pylori DNA in gastric juice by the polymerase chain reaction: Comparison with findings in bacterial culture and the detection of tissue IgA and serum IgG antibodies against Helicobacter pylori
- LECTIN HISTOCHEMICAL STUDIES ON GASTRIC INTESTINAL METAPLASIA WITH ULEX EUROPAEUS AGGLUTININ-I DOLICHOS BIFLORUS AND PEANUT AGGLUTININS IN COMPARISON WITH GASTRIC AND SMALL AND LARGE INTESTINAL MUCOSA
- Expression of interleukin-6 and tumor necrosis factor in peritoneal mononuclear cells after gastrectomy