Hepatic Disposition Characteristics of Recombinant Human Interleukin-11 (rhIL-11) in the Perfused Rat Liver
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概要
- 論文の詳細を見る
The hepatic disposition characteristics of recombinant human interleukin-11 (rhIL-11) were investigated in perfused rat liver to clarify the mechanism of hepatic clearance which is a major contributor to the rapid clearance of rhIL-11 in vivo. We analyzed the disposition characteristics of [^<111>In]-labeled rhIL-11 using a single-pass constant infusion mode at different concentrations of rhIL-11. The venous outflow rapidly reached a steady-state condition at every concentration. Liver extraction ratio at steady-state (E_<SS>) was decreased with increase in the concentration, suggesting that there is a saturable interaction between the liver cells and rhIL-11 molecule. Cellular localization experiments demonstrated that rhIL-11 was taken up by both liver parenchymal and non-parenchymal cells depending on their surface area, suggesting that this uptake was mediated by electrostatic interaction due to cationic charges in the cytokine.
- 社団法人日本薬学会の論文
- 1998-12-15
著者
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Hashida Mitsuru
Department Of Basic Pharmaceutics Faculty Of Pharmaceutical Sciences Kyoto University
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Hashida Mitsuru
Department Of Drug Delivery Research Graduate School Of Pharmaceutical Sciences Kyoto University
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Hashida M
Departments Of Drug Delivery Research Graduate School Of Pharmaceutical Sciences Kyoto University
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YABE Yoshiyuki
Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University
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Yabe Yoshiyuki
京都大学 薬学研究科薬品動態制御学
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Yabe Yoshiyuki
Department Of Drug Delivery Research Graduate School Of Pharmaceutical Sciences Kyoto University
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Takagi Akira
Post Marketing Product Development Astellas Pharma Inc.
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Hashida M
Department Of Drug Delivery Research Graduate School Of Pharmaceutical Sciences Kyoto University
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TAKAKURA Yoshinobu
Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University
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TAKAGI Akira
Novel Pharmaceutical Laboratories, Yamanouchi Pharmaceutical Co., Ltd.,
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YOSHIDA Mitsunobu
Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University
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Takakura Yoshinobu
Department Of Basic Pharmaceutics Faculty Of Pharmaceutical Sciences Kyoto University
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Takakura Yoshinobu
Department Of Drug Delivery Research Graduate School Of Pharmaceutical Sciences Kyoto University
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Takagi A
Department Of Dds Research Novel Pharmaceutical Research Laboratories Institute For Drug Development
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Yoshida Mitsunobu
Department Of Drug Delivery Research Graduate School Of Pharmaceutical Sciences Kyoto University
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