Unique Cytokine Production Profile Following Stimulation with DNA in Macrophages from NZB/W F_1 Mice(Miscellaneous)
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概要
- 論文の詳細を見る
Nucleosome is the major autoantigen in systemic lupus erythematosus (SLE). Professional antigen-presenting cells (APCs), such as macrophages (MΦs) and dendritic cells (DCs), play the central roles in the acquisition of Ag-speciflc immune responses and activation of such APCs is required for the efficient Ag-presentation. Therefore, adjuvant activity of DNA in nucleosomes would cause the prominent effects on the production of anti-nucleosome antibodies. In this study, we report that elicited peritoneal MΦs from New Zealand Black/White F_1 (NZB/W) mice showed a unique cytokine production profile following stimulation with DNA. MΦs from 5-week old NZB/W mice produced a higher amount of IL-6 and about a half amount of TNF-α after stimulation with DNA complexed with cationic liposomes compared with those from control ICR mice. These results suggest that MΦs of NZB/W mice have altered responsiveness to DNA and this might elevate the antigenicity of nucleosomes to induce the production of anti-nucleosome antibodies.
- 公益社団法人日本薬学会の論文
- 2008-06-01
著者
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NISHIKAWA Makiya
Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University
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OGAWA Yoshiyuki
Department of Hematology, National Hospital Organization Nishigunma National Hospital
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Ogawa Yoshiyuki
Department Of Biopharmaceutics And Drug Metabolism Graduate School Of Pharmaceutical Sciences Kyoto
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TAKAKURA Yoshinobu
Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University
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YOSHINAGA Takaharu
Department of Biopharmaceutics and Drug Metabolism, Graduate School of Pharmaceutical Sciences, Kyot
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Nishikawa Makiya
Department Of Biopharmaceutics And Drug Metabolism Graduate School Of Pharmaceutical Sciences Kyoto
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Nishikawa Makiya
Department Of Biopharmaceutics And Drug Metabolism Graduate School Of Pharmaceutical Science Kyoto U
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Yoshinaga Takaharu
Department Of Biopharmaceutics And Drug Metabolism Graduate School Of Pharmaceutical Sciences Kyoto
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Takakura Yoshinobu
Department Of Basic Pharmaceutics Faculty Of Pharmaceutical Sciences Kyoto University
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Takakura Yoshinobu
Department Of Biopharmaceutics And Drug Metabolism Graduate School Of Pharmaceutical Sciences Kyoto
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Ogawa Yoshiyuki
Department Of Bioengineering Nagaoka University Of Technology
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