INTERACTIONS BETWEEN BACTERIAL PYROGEN AND PROTEOLIPID EXTRACTED FROM THE CEREBRUM (III) VARIATION IN AFFINITY OF PROTEOLIPID PROTEINS DERIVED FROM RABBIT, RAT AND CHICKEN CEREBRUMS TO BACTERIAL PYROGEN
スポンサーリンク
概要
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We undertook comparative studies on the binding of cerebral proteolipids to LPS using rabbits, rats and chickens in order to clarify the differences in inactivating effects of proteolipids from these three sources on the pyrogenicity of LPS. The Sephadex LH-20 column elution profiles of lipid phosphorus and cerebrosides were not significantly different for the three sources of proteolipid, but a larger amount of proteolipid-protein possessing LPS pyrogenicity inactivating potency was eluted with chloroform(C)/methanol(M) (4:1) in rats and chickens than in rabbits. A complex of proteolipid-protein with LPS was obtained in C effluent from incubation mixtures of rat and chicken proteolipids with LPS, corresponding to our previous observation with rabbit proteolipid. The increasing order of binding capacity of the proteolipids derived from the three species was as follows: chicken, rat and rabbit, which was in parallel with pyrogenic inactivating potency. From these data, we suggest that the difference in pyrogenic inactivating potency among the proteolipids of some species depnds on the difference in binding capacity of the proteolipids to LPS or probably lipid A.
- 社団法人 日本薬理学会の論文
著者
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OGAWA Yoshiyuki
Department of Hematology, National Hospital Organization Nishigunma National Hospital
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KANOH SEIZABURO
Department of Pharmacology and Bacteriology, National Institute of Hygienic Sciences, Osaka Branch
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Kanoh Seizaburo
Department Of Forensic Medicine Wakayama Prefectural Medical College
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Ogawa Yoshiyuki
Department Of Bioengineering Nagaoka University Of Technology
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KANOH Seizaburo
Department of Pharmacology, National Institute of Hygienic Sciences
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OGAWA Yoshiyuki
Department of Pharmacology, National Institute of Hygienic Sciences
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