Combination of Bubble Liposomes and High-Intensity Focused Ultrasound (HIFU) Enhanced Antitumor Effect by Tumor Ablation

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概要

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• Ultrasound (US) is used in the clinical setting not only for diagnosis but also for therapy. As a therapeutic US technique, high-intensity focused ultrasound (HIFU) can be applied to treat cancer in a clinical setting. Microbubbles increased temperature and improved the low therapeutic efficiency under HIFU; however, microbubbles have room for improvement in size, stability, and targeting ability. To solve these issues, we reported that "Bubble liposomes" (BLs) containing the US imaging gas (perfluoropropane gas) liposomes were suitable for ultrasound imaging and gene delivery. In this study, we examined whether BLs and HIFU could enhance the ablation area of the tumor and the antitumor effect. First, we histologically analyzed the tumor after BLs and HIFU. The ablation area of the treatment of BLs and HIFU was broader than that of HIFU alone. Next, we monitored the temperature of the tumor, and examined the antitumor effect. The temperature increase with BLs and HIFU treatment was faster and higher than that with HIFU alone. Moreover, treatment with BLs and HIFU enhanced the antitumor effect, which was better than with HIFU alone. Thus, the combination of BLs and HIFU could be efficacious for cancer therapy.

• 公益社団法人 日本薬学会の論文

著者

• Yamashita Fumiyoshi

  Department Of Drug Delivery Research Graduate School Of Pharmaceutical Sciences Kyoto University

• Hashida Mitsuru

  Department Of Basic Pharmaceutics Faculty Of Pharmaceutical Sciences Kyoto University

• Hamano Nobuhito

  Department of Drug and Gene Delivery Systems, School of Pharmacy, Tokyo University of Pharmacy and L

• Endo-Takahashi Yoko

  Department of Drug and Gene Delivery Systems, School of Pharmacy, Tokyo University of Pharmacy and L

• Aramaki Yukihiko

  Department of Drug and Gene Delivery Systems, School of Pharmacy, Tokyo University of Pharmacy and L

• Niidome Takuro

  Department Of Applied Chemistry Faculty Of Engineering And Center For Future Chemistry Kyushu Univer

• Sasaki Hitoshi

  Laboratory Of Entomology Department Of Dairy Science Rakuno Gakuen University

• Suzuki Ryo

  Department Of Biological And Chemical Engineering Gunma University

• Negishi Yoichi

  Department of Chemical Engineering, Yokohama National University

• Endo-Takahashi Yoko

  Department of Drug Delivery and Molecular Biopharmaceutics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences

• Takatori Kyohei

  Department of Drug Delivery and Molecular Biopharmaceutics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences

• Suzuki Ryo

  Laboratory of Drug and Gene Delivery Research, Faculty of Pharma-sciences, Teikyo University

• Maruyama Kazuo

  Laboratory of Drug and Gene Delivery Research, Faculty of Pharma-sciences, Teikyo University

• Aramaki Yukihiko

  Department of Drug Delivery and Molecular Biopharmaceutics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences

• Negishi Yoichi

  Department of Drug Delivery and Molecular Biopharmaceutics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences

• Niidome Takuro

  Department of Applied Chemistry and Biochemistry, Graduate School of Science and Technology

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