Sedative Effects of Inhaled Benzylacetone and Structural Features Contributing to Its Activity
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概要
- 論文の詳細を見る
Benzylacetone is released by heated agarwood, when inhaled it has a potent effect on reducing the locomotor activity of mice. This study investigated the relationships between the sedative activities of benzylacetone and its derivatives as well as the chemical structures of these compounds by comparing their activities in mice treated with a series of compounds. It was demonstrated that benzylacetone-like compounds had sedative activities and their intensities varied depending on the functional group in the carbon chain, the substituent in the benzene ring, and their combinations. A quantitative structure–activity relationship study was carried out using a series of 17 benzylacetone derivatives to determine the structural features with significant for the sedative activity.
著者
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Yamashita Fumiyoshi
Department Of Drug Delivery Research Graduate School Of Pharmaceutical Sciences Kyoto University
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Ito Michiho
Department Of Pharmacognosy Graduate School Of Pharmaceutical Science Kyoto University
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Miyoshi Takashi
Department 4 Technology Research Division 2 Honda R&d Co. Ltd. Automobile R&d Center
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Kitayama Takashi
Department Of Advanced Bioscience Graduate School Of Agriculture Kinki University
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Isomori Sachiko
Department of Advanced Bioscience, Graduate School of Agriculture, Kinki University
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Miyoshi Takashi
Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Kyoto University
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