.ALPHA.-Phenyl-N-tert-butyl Nitrone Has Scavenging Activity Against Singlet Oxygen (1O2) and Attenuates 1O2-Induced Neuronal Cell Death
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概要
- 論文の詳細を見る
Scavenging activity of α-phenyl-N-tert-butyl nitrone (PBN) against singlet oxygen (1O2) and its effects on 1O2-induced neuronal cell death were examined. PBN at 1 – 4 mM dose-dependently suppressed 1O2 released from activated human neutrophils. PBN did not react with hydrogen peroxide or hypochlorite and did not affect myeloperoxidase activity, which are involved in the 1O2 formation in neutrophils. PBN also suppressed chemically generated 1O2 in a cell-free system. These findings collectively indicated that PBN certainly has scavenging activity against 1O2. Furthermore, PBN attenuated 1O2-induced neuronal cell death. The well-known neuroprotective effects of PBN might be attributed to its 1O2-scavenging activity.
- 公益社団法人 日本薬理学会の論文
著者
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Miyoshi Takashi
Department 4 Technology Research Division 2 Honda R&d Co. Ltd. Automobile R&d Center
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Mori Hiroko
Department of Anesthesia, Higashiyama Takeda Hospital
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Nishinaka Yoko
School of Health Science, Faculty of Medicine, Kyoto University
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ENDO Nobuyuki
Wakasa Wan Energy Research Center
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Yamashita Kouhei
Department Of Hematology And Oncology Graduate School Of Medicine Kyoto University
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Sasada Masataka
School Of Health Science Faculty Of Medicine Kyoto University
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Arai Toshiyuki
Department Of Anesthesia Kyoto University Hospital
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Kawai Anna
School Of Health Science Faculty Of Medicine Kyoto University
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Hirota Kiichi
Department Of Anesthesia Kitano Hospital The Tazuke Kofukai Medical Research Institute
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Kawai Anna
School of Health Science, Faculty of Medicine, Kyoto University, Japan
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Arai Toshiyuki
Department of Anesthesia, Kyoto University Hospital, Japan
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Yamashita Kouhei
Department of Hematology and Oncology, Kyoto University Hospital, Japan
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Endo Nobuyuki
Wakasa Wan Energy Research Center, Japan
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Sasada Masataka
School of Health Science, Faculty of Medicine, Kyoto University, Japan
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Nishinaka Yoko
School of Health Science, Faculty of Medicine, Kyoto University, Japan
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