Effects of Injectable Propofol Emulsion on Singlet Oxygen Released From Activated Human Neutrophils and That Chemically Generated

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概要

• 論文の詳細を見る

• Effects of an injectable emulsion of propofol and its emulsifier on singlet oxygen (1O2) were examined. 1O2 released from activated human neutrophils was detected by chemiluminescence, and chemically generated 1O2 was detected by electron paramagnetic resonance (EPR). Both the propofol emulsion and the emulsifier suppressed 1O2 release from neutrophils. However, the emulsifier did not quench chemically generated 1O2, while the propofol emulsion quenched it. These results indicated that the emulsifier did not scavenge 1O2 released from neutrophils but inhibited 1O2 generation. The suppressive effects of propofol emulsion on 1O2 release from neutrophils consist of 1O2 scavenging and inhibition of 1O2 generation.

• 社団法人 日本薬理学会の論文
• 2008-08-20

著者

• Miyamoto Tadashi

  Department Of Cardiology Hyogo Prefectural Amagasaki Hospital

• Morimoto Takeshi

  神戸市立医療センター中央市民病院 循環器内科

• Miyoshi Takashi

  Department of Mechanical Engineering and Systems, Osaka University

• Morimoto Tatsuya

  Center For Medical Education Kyoto University Graduate School Of Medicine

• Takahashi Masao

  Department Of Cardiovascular Medicine University Of Tokyo

• YAMASHITA Kouhei

  Department of Hematology and Oncology, Kyoto University Hospital

• SASADA Masataka

  School of Health Science Faculty of Medicine, Kyoto University

• Miyoshi Takashi

  Department 4 Technology Research Division 2 Honda R&d Co. Ltd. Automobile R&d Center

• Nonogawa Mitsuru

  Institute Of Advanced Energy Kyoto University

• Mori Hiroko

  Department of Anesthesia, Higashiyama Takeda Hospital

• Nishinaka Yoko

  School of Health Science, Faculty of Medicine, Kyoto University

• Arai Toshiyuki

  Department of Anesthesia, Kyoto University Hospital

• SENDA Chika

  School of Health Science, Faculty of Medicine, Kyoto University

• SEGAWA Hajime

  Department of Anesthesia, Kyoto University Hospital

• ENDO Nobuyuki

  Wakasa Wan Energy Research Center

• Yamashita Kouhei

  Dep. Of Hematology And Oncology Kyoto Univ. Hospital

• Yamashita Kouhei

  Department Of Hematology And Oncology Graduate School Of Medicine Kyoto University

• Yamashita Kouhei

  Department Of Hematology And Oncology Kyoto University Hospital

• Sasada Masataka

  School Of Health Science Faculty Of Medicine Kyoto University

• Senda Chika

  School Of Health Science Faculty Of Medicine Kyoto University

• Arai Toshiyuki

  Department Of Anesthesia Kyoto University Hospital

• Segawa Hajime

  Department Of Anesthesia And Division Of Critical Care Medicine Kyoto University Hospital

• Morota Tetsuro

  Department Of Cardiology The University Of Tokyo

• Miyoshi Takashi

  Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo

• Makiyama Takeru

  Department Of Nephrology And Rheumatology Tosei General Hospital

• Miyoshi Takashi

  Department Of Hematology And Oncology Kyoto University Hospital

• Miyamoto Tadashi

  Center For Medical Education And Clinical Epidemiology Unit Graduate School Of Medicine Kyoto Univer

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