Anticancer Photodynamic and Non-photodynamic Effects of Pterin Derivatives on a Pancreatic Cancer Cell Line
スポンサーリンク
概要
- 論文の詳細を見る
To evaluate the feasibility of two kinds of pterin derivatives, 2-(N,N-dimethylaminomethyleneamino)-6-formyl-3-pivaloylpteridin-4-one (DFP) and 2-(N,N-dimethylaminomethyleneamino)-3-pivaloylpteridin-4-one (DP), as anticancer drugs, their photodynamic and non-photodynamic effects on pancreatic cancer cell line Panc-1 cells were examined. For photodynamic effects, cell death 48 h after UV-A irradiation was more prominent in cells preloaded with DP than DFP. When cells were simply incubated for 96 h without irradiation, DFP induced cell death, while DP suppressed cell proliferation. Furthermore, DP was much more soluble in water than DFP. These findings collectively indicated that DP is more feasible as an anticancer drug than DFP.
- 社団法人 日本薬理学会の論文
- 2008-06-20
著者
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Miyamoto Tadashi
Department Of Cardiology Hyogo Prefectural Amagasaki Hospital
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Morimoto Takeshi
神戸市立医療センター中央市民病院 循環器内科
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Miyoshi Takashi
Department of Mechanical Engineering and Systems, Osaka University
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Morimoto Tatsuya
Center For Medical Education Kyoto University Graduate School Of Medicine
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Takahashi Masao
Department Of Cardiovascular Medicine University Of Tokyo
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YAMASHITA Kouhei
Department of Hematology and Oncology, Kyoto University Hospital
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SASADA Masataka
School of Health Science Faculty of Medicine, Kyoto University
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Miyoshi Takashi
Department 4 Technology Research Division 2 Honda R&d Co. Ltd. Automobile R&d Center
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Nonogawa Mitsuru
Institute Of Advanced Energy Kyoto University
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Mori Hiroko
Department of Anesthesia, Higashiyama Takeda Hospital
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Makino Keisuke
Institute of Advanced Energy, Kyoto University
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Arai Toshiyuki
Department of Anesthesia, Kyoto University Hospital
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Yamashita Kouhei
Dep. Of Hematology And Oncology Kyoto Univ. Hospital
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Yamashita Kouhei
Department Of Hematology And Oncology Graduate School Of Medicine Kyoto University
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Yamashita Kouhei
Department Of Hematology And Oncology Kyoto University Hospital
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Sasada Masataka
School Of Health Science Faculty Of Medicine Kyoto University
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Arai Toshiyuki
Department Of Anesthesia Kyoto University Hospital
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Makino Keisuke
Inst. Of Advanced Energy Kyoto Univ.
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Makino Keisuke
Institute Of Advanced Energy Kyoto University
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Morota Tetsuro
Department Of Cardiology The University Of Tokyo
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Miyoshi Takashi
Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo
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Makiyama Takeru
Department Of Nephrology And Rheumatology Tosei General Hospital
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Miyoshi Takashi
Department Of Hematology And Oncology Kyoto University Hospital
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Miyamoto Tadashi
Center For Medical Education And Clinical Epidemiology Unit Graduate School Of Medicine Kyoto Univer
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