Effects of Edaravone on Singlet Oxygen Released From Activated Human Neutrophils

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概要

• 論文の詳細を見る

• The effects of edaravone, a curative agent for acute brain infarction, on singlet oxygen (1O2) released from activated human neutrophils were examined, and the effects were compared to those of histidine, a 1O2 singlet oxygen scavenger. The neutrophils, stimulated with opsonized zymosan, released 1O2 that was detected by chemiluminescence using a 1O2 specific probe, trans-1-(2-methoxyvinyl)pyrene. Edaravone dose-dependently suppressed the 1O2 release with an IC50 of approximately 0.3 μM, while the IC50 of histidine was approximately 1 mM. This 1O2 scavenging activity of edaravone might be involved in its curative effects on acute brain infarction.

• 社団法人 日本薬理学会の論文
• 2007-01-20

著者

• Miyamoto Tadashi

  Department Of Cardiology Hyogo Prefectural Amagasaki Hospital

• Morimoto Takeshi

  神戸市立医療センター中央市民病院 循環器内科

• Miyoshi Takashi

  Department of Mechanical Engineering and Systems, Osaka University

• Morimoto Tatsuya

  Center For Medical Education Kyoto University Graduate School Of Medicine

• Takahashi Masao

  Department Of Cardiovascular Medicine University Of Tokyo

• YAMASHITA Kouhei

  Department of Hematology and Oncology, Kyoto University Hospital

• Miyoshi Takashi

  Department 4 Technology Research Division 2 Honda R&d Co. Ltd. Automobile R&d Center

• Mori Hiroko

  Department of Anesthesia, Higashiyama Takeda Hospital

• Sommani Piyanart

  Institute of Advanced Energy, Kyoto University

• Makino Keisuke

  Institute of Advanced Energy, Kyoto University

• Arai Toshiyuki

  Department of Anesthesia, Kyoto University Hospital

• Yamashita Kouhei

  Dep. Of Hematology And Oncology Kyoto Univ. Hospital

• Yamashita Kouhei

  Department Of Hematology And Oncology Graduate School Of Medicine Kyoto University

• Yamashita Kouhei

  Department Of Hematology And Oncology Kyoto University Hospital

• Sasada Masataka

  School Of Health Science Faculty Of Medicine Kyoto University

• Arai Toshiyuki

  Department Of Anesthesia Kyoto University Hospital

• Sommani Piyanart

  Inst. Of Advanced Energy Kyoto Univ.

• Makino Keisuke

  Inst. Of Advanced Energy Kyoto Univ.

• Makino Keisuke

  Institute Of Advanced Energy Kyoto University

• Morota Tetsuro

  Department Of Cardiology The University Of Tokyo

• SASADA Masataka

  Department of Anesthesia, Higashiyama Takeda Hospital

• Miyoshi Takashi

  Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo

• Makiyama Takeru

  Department Of Nephrology And Rheumatology Tosei General Hospital

• Miyoshi Takashi

  Department Of Hematology And Oncology Kyoto University Hospital

• Miyamoto Tadashi

  Center For Medical Education And Clinical Epidemiology Unit Graduate School Of Medicine Kyoto Univer

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