Gastrointestinal follicular lymphoma: review of the literature.
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概要
- 論文の詳細を見る
Gastrointestinal follicular lymphoma (GI-FL) is a relatively rare disease, accounting for only 1%-3.6% of gastrointestinal non-Hodgkin's lymphoma. Although the duodenum and terminal ileum are considered to be the most common sites of origin, the development of wireless capsule endoscopy and double-balloon enteroscopy has increased the detection of GI-FL in every part of the small intestine. Approximately 70% of patients with GI-FL are estimated to have multiple lesions throughout the entire gastrointestinal tract. FL is a low-grade lymphoma that usually develops very slowly. If the lymphoma causes no symptoms, immediate treatment may not be necessary. Standard therapy has not yet been established for GI-FL, but chemotherapy, radiotherapy, monoclonal antibody therapy, or a combination of these therapies, is sometimes performed based on the therapeutic regimens for nodal FL. Regimens including conventional chemotherapy with rituximab, which achieve high response rates in nodal FL, are commonly used for GI-FL. The long-term clinical outcome of GI-FL is unclear. The results of a few series on the long-term outcomes of patients with GI-FL treated with conventional therapy indicate a median relapse-free time ranging from 31 to 45 months. On the other hand, in patients with GI-FL who were followed without treatment, the median time to disease progression was 37.5 months. Thus, whether to initiate aggressive therapy or whether to continue watchful waiting in patients with GI-FL is a critically important decision. Ongoing research on biomarkers to guide individualized GI-FL therapy may provide invaluable information that will lead to the establishment of a standard therapeutic regimen.
- 2010-04-01
著者
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Chiba Tsutomu
Department of Gastroenterology and Hepatology, Shimane Medical University
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YAMAMOTO Shuji
Department of Radiology, Osaka University Hospital
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YAMASHITA Kouhei
Department of Hematology and Oncology, Kyoto University Hospital
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Chiba Tsutomu
Department Of Gastroenterology & Hepatology Graduate School Of Medicine Kyoto University
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Chiba Tsutomu
京都大学 消化器内科学
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Chihara Kazuo
Division Of Diabetes Metabolism And Endocrinology Department Of Internal Medicine Kobe University Gr
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Chiba T
京都大学 消化器内科学
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NAKASE Hiroshi
Departments of Gastroenterology and Endoscopic Medicine, Kyoto University Hospital
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MATSUURA MINORU
Department of Endoscopic Medicine and Gastroenterology, Kyoto University Hospital
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Chiba Tsutomu
Division Of Gastroenterology And Hepatology Department Of Medicine Kyoto University Graduate School
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Chiba Tsutomu
Division Of Gastroenterology And Hepatology Department Of Medicine Graduate School Of Medicine Kyoto
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Chiba Tsutomu
Department Of Gastroenterology And Hepatology Graduate School Of Medicine Kyoto University
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Chiba Tsutomu
Department Of Gastroenterology And Hepatology Kyoto University
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Chiba Tsutomu
Deparment Of Gastroenterology And Hepatology Kyoto University Graduate School Of Medicine
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China Toshiya
Department Of Pathology Tsukuba Medical Center
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Nakase Hiroshi
Departments Of Gastroenterology And Endoscopic Medicine Kyoto University Hospital
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Nakase Hiroshi
Division Of Applied Life Sciences Graduate School Of Agriculture Kyoto University
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Nakase Hiroshi
Department Of Gastroenterology & Hepatology Graduate School Of Medicine Kyoto University
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Nakase Hiroshi
Department Of Agricultural Chemistry Faculty Of Agriculture Kyoto University
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Matsushita Mitsunobu
Third Department Of Internal Medicine Kansai Medical University
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Yamashita Kouhei
Department Of Hematology And Oncology Graduate School Of Medicine Kyoto University
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Chiba Tsutomu
Department Of Gastroenterology And Hepatology Shimane Medical University
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Yazumi Shujiro
Department Of Gastroenterology And Hepatology Graduate School Of Medicine Kyoto University
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Nakase Hiroshi
Department Of Gastroenterology And Hepatology Kyoto University Graduate School Of Medicine
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TAKADA Mariko
Department of Gastroenterology, Kobe City Medical Center General Hospital
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KAWANAMI Chiharu
Department of Gastroenterology, Kobe City Medical Center General Hospital
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Takada Mariko
Department Of Gastroenterology Kobe City Medical Center General Hospital
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Matsushita Mitsunobu
The Third Department Of Internal Medicine Division Of Gastroenterology And Hepatology Kansai Medical
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Yazumi Syuziro
Department Of Gastroenterology And Hepatology Graduate School Of Medicine Kyoto University
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Matsuura Minoru
Department Of Gastroenterology And Hepatology Graduate School Of Medicine Kyoto University
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Kawanami Chiharu
The Division Of Gerontology Department Of Medicine Kobe University School Of Medicine The Department
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Kawanami Chiharu
Department Of Gastroenterology Kobe City Medical Center General Hospital
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Yamamoto Shuji
Department Of Hematology And Oncology University Of Fukui
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Kawanami Chiharu
Department of Gastroenterogy and Hepatology, Graduate School of Medicine, Kyoto University, Japan
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Yamamoto Shuji
Department of Applied Chemistry, Yamanashi University
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