Growth Hormone Stimulates Mechano Growth Factor Expression and Activates Myoblast Transformation in C2C12 cells

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概要

• 論文の詳細を見る

• Mechano growth factor (MGF) is an alternatively spliced variant of insulin-likegrowth factor-I (IGF-I). Previous reports have revealed that the MGF in skeletalmuscles is induced by mechanical overload or muscle injury. In the present study, weexamined the effect of growth hormone (GH) on MGF expression in C2C12 mousemuscle cell lines since GH is the principal regulator of IGF-I. The MGF mRNAincreased 1 h following GH stimulation whereas IGF-IEa mRNA, which encodes asystemic type of IGF-I, increased 4 h following GH stimulation. The diverse expressionof MGF and IGF-IEa was also observed in the case of muscle injury by usingbupivacaine in the same cell line. Furthermore, GH induced the increase of MyoD aswell as M-cadherin expression, the peak of which was parallel to that of MGF. Theseresults indicate that GH directly and preferentially increased MGF prior to theIGF-IEa expression in C2C12 cells, which may lead to the activation of muscle satellitecells.

• 神戸大学の論文

著者

• Chihara Kazuo

  Kobe University Graduate School of Medicine

• Iida Keiji

  神戸大学 医学研究科内科学講座糖尿病代謝内分泌内科学

• Iida Keiji

  Division Of Diabetes Metabolism And Endocrinology Department Of Internal Medicine Kobe University Gr

• Chihara K

  Division Of Diabetes Metabolism And Endocrinology Department Of Internal Medicine Kobe University Gr

• Chihara Kazuo

  Division Of Diabetes Metabolism And Endocrinology Department Of Internal Medicine Kobe University Gr

• Kasai Hiroshi

  Department Of Environmental Oncology Institute Of Industrial Ecological Sciences University Of Occup

• Takahashi Yutaka

  Division Of Diabetes Metabolism And Endocrinology Department Of Internal Medicine Kobe University Gr

• TAKENO RYOKO

  Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University

• KAJI HIDESUKE

  College of Nursing Art and Culture 13-71

• OKIMURA YASUHIKO

  Department of Basic Allied Medicine, Kobe University School of Medicine

• Imanaka Mari

  Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe Universit

• Murawaki Ayumi

  Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe Universit

• Nishizawa Hitoshi

  Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe Universit

• Fukuoka Hidenori

  Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe Universit

• Kaji Hidesuke

  Division of Physiology&Metabolism, University of Hyogo

• Murawaki Ayumi

  Division Of Diabetes Metabolism And Endocrinology Department Of Internal Medicine Kobe University Gr

• Kasai H

  Department Of Environmental Oncology University Of Occupational And Environmental Health

• Nishizawa Hitoshi

  Division Of Diabetes Metabolism And Endocrinology Department Of Internal Medicine Kobe University Gr

• Kasai H

  Department Of Environmental Oncology Institute Of Industrial Ecological Sciences University Of Occup

• Okimura Yasuhiko

  Department Of Basic Allied Medicine Kobe University School Of Medicine

• Imanaka Mari

  Division Of Diabetes Metabolism And Endocrinology Department Of Internal Medicine Kobe University Gr

• Takeno Ryoko

  Division Of Diabetes Metabolism And Endocrinology Department Of Internal Medicine Kobe University Gr

• Kasai H

  Division Of Diabetes Metabolism And Endocrinology Department Of Internal Medicine Kobe University Gr

• Fukuoka Hidenori

  Division Of Diabetes Metabolism And Endocrinology Department Of Internal Medicine Kobe University Gr

• Iida Keiji

  Division Of Diabetes Metabolism And Endocrinology Department Of Internal Medicine Kobe University Gr

• Iida Keiji

  Division Of Diabetes And Endocrinology Hyogo Prefectural Kakogawa Medical Center

• Chihara Kazuo

  Division Of Diabetes And Endocrinology Hyogo Prefectural Kakogawa Medical Center

• FUKUOKA Hidenori

  Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine

• NISHIZAWA Hitoshi

  Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine

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