Direct effects of Tumor Necrosis Factor Alpha(TNF-α) on L6 Myotubes
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概要
- 論文の詳細を見る
Tumor necrosis factor (TNF)-α is a pleiotropic cytokine responsible for a diverserange of signaling events within cells. We studied direct effects of TNF-α on skeletalmuscle protein content. Incubation of the L6 myotubes with 1 to 10 U/ml of TNF-αresulted in a significant increase of total and myofibrillar protein contents as comparedwith the control. However, incubation with lower (0.001-0.1 U/ ml) or higher (100-300U/ml) doses of TNF-α resulted in a decrease of protein content. These findings suggestthat TNF-α may elicit both anabolic and catabolic effects on L6 myotubes in a dosedependent manner. The anabolic effect of TNF-α was mediated at least in part bymitogen activated protein kinase (MAPK), especially by an extracellular-regulatedkinases (ERK). This divergent effect of TNF-α may be crucial to elucidate thecomplexity of TNF-α action on the skeletal muscle.
- 神戸大学の論文
著者
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Chihara Kazuo
Kobe University Graduate School of Medicine
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Chihara Kazuo
Division Of Diabetes Metabolism And Endocrinology Department Of Internal Medicine Kobe University Gr
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Okuda Shiho
Kobe University Graduate Schoolof Medicine
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Kanda F
Kobe University Graduate Schoolof Medicine
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Kanda Fumio
Kobe University Graduate Schoolof Medicine
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Naggar Enas
Kobe University Graduate Schoolof Medicine
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Maeda Nobuya
Kobe University Graduate Schoolof Medicine
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Nishimoto Keisuke
Kobe University Graduate Schoolof Medicine
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Ishihara Hiroyuki
Kobe University Graduate Schoolof Medicine
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Kawanami Chiharu
The Division Of Gerontology Department Of Medicine Kobe University School Of Medicine The Department
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Maeda Nobuya;
Kobe University Graduate Schoolof Medicine
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