Studies on the Mechanism Controlling Growth Hormone Release Induced by Chlorpromazine in the Anesthetized Rat
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概要
- 論文の詳細を見る
In intact urethane-anesthetized rats, plasma growth hormone (GH) levels were low but increased significantly following intravenous injection of chlorpromazine. Plasma GH levels were significantly elevated in rats with hypothalamic cuts such as complete deafferentation, anterior cut and antero-lateral cut, whereas plasma GH levels in rats with posterior cut or postero-lateral cut were not significantly different from those in rats with sham-operation. Intravenous injection of chlorpromazine caused an increase of plasma GH in rats with any type of hypothalamic cut. However, the maximum increments of plasma GH following chlorpromazine were larger in rats with antero-lateral cut and smaller in rats with posterior cut than in rats with sham-operation. These results suggest that extrahypothalamic inhibiting and stimulating neurons influence the regulatory mechanism of rat GH secretion through anterior and posterior routes to the hypothalamus respectively.
- 社団法人 日本内分泌学会の論文
著者
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Chihara Kazuo
Kobe University Graduate School of Medicine
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Chihara K
Division Of Diabetes Metabolism And Endocrinology Department Of Internal Medicine Kobe University Gr
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Chihara Kazuo
Third Division Department Of Medicine Kobe University
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KATO YUZURU
Third Division, Department of Medicine Kobe University School of Medicine
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OHGO SHOZO
Third Division, Department of Medicine Kobe University School of Medicine
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Imura Hiroo
Third Division Department Of Medicine Kobe University School Of Medicine
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