Diabetes Insipidus and Galactorrhea Caused by Histiocytosis X
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概要
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A 44-year-old woman with diabetes insipidus of 3 years duration was found to have histiocvtosis X. This was based on clinical, radiological and pathological findings consistent with the diagnosis. Furthermore, she developed spontaneous galactorrhea during the course. Endocrine studies of hypothalamic-pituitary function revealed completely impaired secretion of gonadotropin, growth hormone and antidiuretic hormone, and possible partial impairment of adrenocorticotropic hormone secretion, while thyroid stimulating hormone secretion remained intact. Persistently elevated plasma levels of human prolactin were also demonstrated, which were unaffected by administration of either thyrotropin releasing hormone, <I>l</I>-DOPA or water loading, but suppressed significantly by CB-154, an ergot alkaloid. These results suggest that abnormalities of the patients endocrine function may be mainly accounted for by a single hypothalamic lesion.
- 社団法人 日本内分泌学会の論文
著者
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Hirata Yukio
Third Division Department Of Medicine Kobe University School Of Medicine
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Matsukura Shigeru
Third Department Of Internal Medicine Miyazaki Medical College
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KATO YUZURU
Third Division, Department of Medicine Kobe University School of Medicine
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SAKAMOTO NOBORU
Third Division, Department of Medicine, Kobe University School of Medicine
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Imura Hiroo
Third Division Department Of Medicine Kobe University School Of Medicine
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YOSHIMOTO YOSHIO
Third Division, Department of Medicine, Kobe University School of Medicine
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YOSHIMOTO YOSHIO
Third Division Department of Medicine, Kobe University School of Medicine
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