Effect of Adrenergic-blocking Agents on Plasma Growth Hormone Response to L-5-Hydroxytryptophan (5-HTP) in Man

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The effects of adrenergic-blocking agents on plasma human growth hormone (hGH) response to L-5-hydroxytryptophan (5-HTP) were studied in man. Oral administration of 150mg of 5-HTP caused a rise in plasma hGH in most of the normal subjects tested, with peak hGH levels of 14.6±2.6ng/m<I>l</I> (mean±SEM). Concomitant administation of propranolol, a beta adrenergic-blocking agent, significantly increased plasma hGH response to 5-HTP. On the contrary, stimulation of growth hormone release by 5-HTP was partially but significantly inhibited by i.v. infusion of phentolamine, an alpha adrenergic-blocking agent. Possible mechanisms by which adrenergic-blocking agents affect plasma hGH response to 5-HTP are discussed.
社団法人日本内分泌学会の論文