Survey Studies on Pituitary Diseases in Japan

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概要

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• This paper represents the results of survey of pituitary diseases in Japan during the 10-year period between 1965 and 1974. All patients who were examined or treated in Japanese general hospitals with more than 80 beds were studied by letters of inquiry. From the study, it was estimated that the total number of patients was as follows: 1130 cases of pituitary dwarfism, 1908 cases of hypopituitarism, 917 cases of acromegaly and gigantism, 745 cases of Cushings disease (adrenal hyperplasia), 1668 cases of pituitary diabetes insipidus. Detailed information was obtained on about half of these patients.<BR>Among patients with pituitary dwarfism, 84% were idiopathic. Idiopathic cases were observed far more frequently in male patients, while no sexual dominancy was observed in secondary cases. In idiopathic cases, the incidence in pathological conditions at the time of delivery was high. Among secondary cases, the predominant causes we crareniopharyngioma and pinealoma. In adult males with hypopituitarism, 42% were due to pituitary adenomas, 19% to craniopharyngiomas and 14% to pinealomas; in adult females, 42% were due to Sheehans disease, 30% to pituitary adenomas, 12% to craniopharyngiomas and only 3% to pinealomas. In patients with acromegaly, the male to female ratio was 1.2: 1; histologically, 72% were acidophilic, 13% chromophobe and 15% mixed pituitary adenomas. In this survey of Cushings disease, Cushings syndrome due to adrenal tumor was 2: 1. The male to female ratio was 1: 3.3 in hyperplasia and 1: 3.9 in adrenal tumor. In patients with pituitary diabetes insipidus, 55% were secondary, 45% idiopathic and 2% familial. The sex ratio between males and females was 1.4: 1. As causes of secondary cases, 25% were due to pinealomas, 16% craniopharygiomas, 13% trauma and 11% other brain tumors.<BR>It was assumed that most of the diagnosed patients were included in this survey; however, an unknown number of patients were escaped, either because they had been misdiagnosed as other diseases, or because they had not yet received a medical examination.

• 社団法人 日本内分泌学会の論文

著者

• Hibi Itsuro

  Department Of Endocrinology & Metabolism National Children's Hospital

• Nakagawa Koji

  Second Department of Internal Medicine, Kyorin University School of Medicine

• Kumahara Yuichi

  Department Of Medicine And Ceriatrics Oska University Medical School

• Imura Hiroo

  Third Division Department Of Medicine Kobe University School Of Medicine

• Saito Shiro

  Department Of Laboratory Medicine School Of Medicine Tokushima University

• SHIMIZU NAOKATA

  First Department of Internal Medicine, University of Tokyo Faculty of Medicine

• IBAYASHI HIROSHI

  Third Department of Internal Medicine, Faculty of Medicine, Kyushu University

• Yoshida Sho

  Department Of Computer Science Kyushu Institute Of Technology

• SHIZUME KAZUO

  The Study Committee on Disorders of Pituitary Function

• HARADA YOSHIMICHI

  Third Department of Medicine, Tottori University School of Medicine

• MIURA KIYOSHI

  Third Department of Internal Medicine, Gifu University School of Medicine

• TOMITA AKIO

  First Department of Internal Medicine, Nagoya University School of Medicine

• DEMURAI HIROSHI

  Department of Internal Medicine, Tokyo Womens Medical College

• SAITO SHIRO

  Department of Laboratory Medicine, Tokushima University School of Medicine

• SAITO SHIRO

  Department of Clinical Laboratory, Tokushima University Hospital, Faculty of Medicine Tokushima University

• HIBI ITSURO

  Department of Endocrinology and Metabolism, National Children's Hospital

• SHIMIZU NAOKATA

  First Department of Internal Medicine, Faculty of Medicine University of Teikyo

• SHIMIZU NAOKATA

  First Department of Medicine, Teikyo University School of Medicine

• DEMURAI HIROSHI

  Department of Internal Medicine, Tokyo Women's Medical College

• NAKAGAWA KOJI

  Second Department of Internal Medicine, Hokkaido University School of Medicine

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