Treatment of idiopathic pituitary dwarfism with methionyl human growth hormone.
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概要
- 論文の詳細を見る
Ten patients with idiopathic pituitary dwarfism were treated with methionyl human growth hormone (met-hGH) produced by recombinant DNA technology. They were given 0.5IU/kg/week of met-hGH for three months. There were no significant changes in physical, blood, urine examinations. Their height increased between 1.5 and 2.7 cm during the 3 months of treatment, which was calculated to be equivalent 6.0 and 10.8 cm per year with a mean increase of 8.7cm.<BR>Anti-hGH antibody was observed in all patients between one and two months of treatment with a titer between 10<SUP>1</SUP>×and 10<SUP>4</SUP>×. In spite of the formation of antibodies, the growth rate did not decrease in 7 of the 10 cases.
- 社団法人 日本内分泌学会の論文
著者
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Hizuka Naomi
Department Of Medicine And Gastroenterology Tokyo Women's Medical University
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Takano Kazue
Department Of Endocrinology Clinical Institute Of Endocrinology Tokyo Women's Medical Universit
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KATO Kiyohiko
Department of Materials Science, Faculty of Engineering, Kitami Institute of Technology
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Hibi Itsuro
Department Of Endocrinology & Metabolism National Children's Hospital
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Kohno Hitoshi
Department Of Endocrinology And Metabolism Fukuoka Children's Hospital
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Sudo Masakatsu
Department Of Pediatrics Fukui Medical School
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Ogawa Masamichi
Department Of Pediatrics Nagoya University
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TAKAHARA Jiro
Department of First Internal Medicine, Kagawa Medical School
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Okada Yoshiaki
Department Of Bacterial And Blood Products National Institute Of Infectious Diseases
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Suwa Seizo
Department Of Endocrinology And Metabolism Kanagawa Children's Medical Center
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KONDO Takuma
Department of Medicine II, Hokkaido University Graduate School of Medicine
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SHIZUME KAZUO
Department of Endocrinology and Endocrine Research Laboratory Toranomon Hospital
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KATO KIYOHIKO
Department of Pediatrics, Yamanashi Medical College
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HIZUKA NAOMI
Department of Internal Medicine Tokyo Women's Medical College
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TAKAHARA JIRO
Department of Medicine, Okayama University
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OKADA YOSHIAKI
Department of Pediatrics, Yodogawa Christian's Hospital
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KOHNO HITOSHI
Department of Pediatrics, Children's Hospital Medical Center
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SUDO MASAKATSU
Department of Pediatrics, Kyoto University
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KONDO TAKUMA
Department of Pediatrics, Children's Medical Center
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