バセドウ病に対する放射性ヨード(^<131>I)治療施行前の適切なヨード制限期間

概要

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Radioactive iodine (^<131>I) treatment for Graves' disease is gradually increasing in Japan. However, the appropriate restriction period of dietary iodine intake before ^<131>I therapy is controversial. To investigate this issue, we studied urinary excretion of iodine (UEI) in 35 patients with Graves' disease admitted to our hospital between February 2002 and September 2004. There was a tendency for a smaller UEI to be associated with higher ^<131>I uptake, and adequate ^<131>I uptake was obtained when UTI was less than 200 μg/day. UEI before iodine restriction was 350 ± 447 μg/day (mean ± SD, n = 35), and less than 200 μ.g/day in 21 cases. UEI in young patients was lower than in older patients. UEI after iodine restriction was decreased to less than 200 μg/day in 12 of 15 patients (80%) in 3 days, and in 13 of 14 patients (92.8%) in 7 days. There was no further decrease in the UEI even when the restriction period was prolonged for up to 14 days. These data suggest that the appropriate restriction period of dietary iodine intake for Graves' patients before 131I treatment is 7 days, and that it may be less than 7 days in younger patients.
東京女子医科大学の論文