Effects of Testosterone and Estradiol on Serum Somatomedin A and Growth Rate of Rats
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概要
- 論文の詳細を見る
The mode of involvement of sex steroids in the growth spurt during adolescence was studied in Wistar rats with a special reference to the level of serum somatomedin A (SMA) determined by radioreceptor assay. Intramuscular administration of testosterone propionate (T; 1 mg/day, alternately for 10 days) to female or gonadectomized male rats provoked a small but significant increase in their body weight or body length without affecting the serum SMA level. In contrast, in hypophysectomized (hypox) male rats T caused a considerable increase in body weight and the serum SMA level only when administered concurrently with bovine growth hormone (bGH; 0.2 U/day, ip). T did not affect the sulfation activity in vitro. These results suggest that androgen participates in the growth spurt during adolescence by enhancing the SMA effect and/or potentiating the SMA production by GH.<BR>Estradiol benzoate (E<SUB>2</SUB>;100μg/day, alternately for 10 days) caused a decrease in the serum SMA level and the growth rate in normal male rats. However, E<SUB>2</SUB> produced an increase in the SMA level when administered to hypox male rats, although the growth was retarded and sulfation potency of the serum was sharply reduced. These results indicate that E<SUB>2</SUB> may suppress the growth by lowering SMA generation in normal rats and cause a production of biologically inactive SMA in hypox male rats.
- 社団法人 日本内分泌学会の論文
著者
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Hizuka Naomi
Department Of Medicine And Gastroenterology Tokyo Women's Medical University
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Takano Kazue
Department Of Endocrinology Clinical Institute Of Endocrinology Tokyo Women's Medical Universit
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Shizume Kazuo
Department of Internal Medioine Tokyo Women's Medical College
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Yamashita Kamejiro
Division Of Endocrinology And Metabolism Department Of Internal Medicine Institute Of Clinical Medic
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Kawai K
Univ. Tsukuba
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OGATA ETSURO
The Fourth Department of Medicine, Faculty of Medicine University of Tokyo
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KAWAI KOICHI
Division of Endocrinology and Metabolism Institute of Clinical Medicine, The University of Tsukuba
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SHIZUME KAZUO
Department of Endocrinology and Endocrine Research Laboratory Toranomon Hospital
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KAWAI KOICHI
Division of Endocrinology and Metabolism, The Institute of Clinical Medicine, The University of Tsukuba
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HIZUKA NAOMI
Department of Internal Medicine Tokyo Women's Medical College
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YAMASHITA KAMEJIRO
Division of Endocrinology and Metabolism, The Institute of Clinical Medicine, The University of Tsukuba
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TAKANO KAZUE
Department of Internal Medicine, Tokyo Women's Medical College
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